Redistribution of Kv2.1 ion channels on spinal motoneurons following peripheral nerve injury

Brain Research
Shannon H RomerR E W Fyffe

Abstract

Pathophysiological responses to peripheral nerve injury include alterations in the activity, intrinsic membrane properties and excitability of spinal neurons. The intrinsic excitability of α-motoneurons is controlled in part by the expression, regulation, and distribution of membrane-bound ion channels. Ion channels, such as Kv2.1 and SK, which underlie delayed rectifier potassium currents and afterhyperpolarization respectively, are localized in high-density clusters at specific postsynaptic sites (Deardorff et al., 2013; Muennich and Fyffe, 2004). Previous work has indicated that Kv2.1 channel clustering and kinetics are regulated by a variety of stimuli including ischemia, hypoxia, neuromodulator action and increased activity. Regulation occurs via channel dephosphorylation leading to both declustering and alterations in channel kinetics, thus normalizing activity (Misonou et al., 2004; Misonou et al., 2005; Misonou et al., 2008; Mohapatra et al., 2009; Park et al., 2006). Here we demonstrate using immunohistochemistry that peripheral nerve injury is also sufficient to alter the surface distribution of Kv2.1 channels on motoneurons. The dynamic changes in channel localization include a rapid progressive decline in cluster si...Continue Reading

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Citations

Oct 4, 2014·Frontiers in Neural Circuits·Adam S DeardorffRobert E W Fyffe
Nov 26, 2016·Physiological Reports·Shannon H RomerRobert E W Fyffe
Mar 27, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sara SalvanyJosep E Esquerda
May 8, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xavier Gallart-PalauJosep E Esquerda
May 31, 2019·The Journal of Physiology·Shannon H RomerRobert E W Fyffe
Oct 27, 2016·PLoS Computational Biology·Nathalie Van HumbeeckJohan Wagemans
Jan 16, 2021·The Journal of Physiology·Adam S DeardorffRobert E W Fyffe
Feb 3, 2021·Physiological Reports·Théo MilleSandrine S Bertrand

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