PMID: 9531143Apr 8, 1998Paper

Redistribution of renal blood flow after SWL evaluated by Gd-DTPA-enhanced magnetic resonance imaging

Journal of Endourology
M R MostafaviP V Prasad

Abstract

Extracorporeal shockwave lithotripsy (SWL) is currently accepted as an effective noninvasive treatment for a wide variety of urinary tract calculi. However, the bioeffects of high-energy shockwaves on renal parenchyma have yet to be fully elucidated. The objective of this study was to measure the acute changes in regional renal hemodynamics associated with SWL utilizing dynamic gadolinium-DTPA-enhanced magnetic resonance imaging (MRI). Seven patients who underwent SWL for renal calculi had an MRI study within 4 hours after the treatment. To assess renal hemodynamics, a bolus of Gd DTPA (0.03 mmol/kg) was administered, and dynamic contrast enhanced images was obtained. Regions of interest (ROI) were defined over the cortex and medulla to obtain signal intensity-v-time curves. The contralateral kidney in each patient was used as the control. The initial slope of the contrast-enhanced signal intensity-v-time curve was used as a measure of the perfusion index (PI). In six patients, perfusion imaging showed a consistent trend of decreased cortical flow (29+/-8%) and a concomitant increase in medullary flow (34+/-14%) in the region of the kidney that was targeted with SWL in six patients (86%). This study shows that renal hemodynamic...Continue Reading

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Citations

Jul 16, 2010·Urological Research·Rajash K Handa, Andrew P Evan
Jun 22, 1999·European Journal of Radiology·P V Prasad, A Priatna
Mar 16, 2001·Journal of Endourology·A J ChanB Saltzman
Mar 1, 2005·Journal of Endourology·Lynn R WillisJames E Lingeman
Apr 8, 2006·American Journal of Physiology. Renal Physiology·Pottumarthi V Prasad
Jul 31, 2001·Radiology·M T Keogan, R R Edelman
Apr 22, 2016·Renal Failure·Sami UğuzAhmet Guven
Oct 19, 2007·BJU International·Michael MitterbergerLeo Pallwein
Feb 3, 2006·Journal of the American Society of Nephrology : JASN·Lynn R WillisJames E Lingeman
Sep 15, 1999·Investigative Radiology·P V PrasadR R Edelman
Aug 25, 1999·Current Opinion in Urology·D A Tolley, P Downey
Feb 9, 2000·Journal of the American Society of Nephrology : JASN·Bret A ConnorsNaomi S Fineberg
Aug 14, 1999·Journal of the American Society of Nephrology : JASN·L R WillisJ E Lingeman

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