Redistribution of synaptic AMPA receptors at glutamatergic synapses in the dorsal cochlear nucleus as an early response to cochlear ablation in rats

Hearing Research
M E Rubio

Abstract

This study investigated whether unilateral deafferentation of the presynaptic neuron is key in the control of morphology and the subunit composition and expression of AMPA type glutamate receptors (GluRs) in neurons of the dorsal cochlear nucleus (DCN). Data showed that there are morphological changes at the postsynaptic sites which precede presynaptic changes at the auditory nerve (AN) synaptic ending in response to peripheral damage, in particular that the postsynaptic densities (PSD) of the AN on fusiform cells (FC) are thicker after denervation. Moreover, GluR2, GluR3 and GluR4 AMPA receptor subunits were redistributed, not only at the synapse of FCs receiving direct contact with the AN, but also at the glutamatergic synapse of the parallel fibers on FC and on cartwheel cells (CwC) which are indirectly innervated by the AN. Interestingly, the same synapses in the DCN contralateral to the lesion and with a normal AN synaptic input also redistributed AMPA receptor subunits at the synapse in respond to deafferentation. In these synapses, there was an increase of immunogold labeling for GluR2/3 subunits but not for GluR2 at 2 days after deafferentation.

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Citations

Jan 28, 2009·Journal of the Association for Research in Otolaryngology : JARO·John R DoucetBradford J May
Mar 11, 2009·Purinergic Signalling·Jonathan R GenzenAngelique Bordey
Mar 13, 2009·Journal of Neurophysiology·Yanjun ZhaoThanos Tzounopoulos
Jan 22, 2013·Brain Research·Guo-Run FanHong-Lian Zhang
Dec 15, 2010·Hearing Research·James A Kaltenbach
May 15, 2007·Current Opinion in Neurobiology·Miwako Masugi-Tokita, Ryuichi Shigemoto
Sep 9, 2010·The Laryngoscope·Alexander W RichPaul B Manis
Aug 15, 2014·Frontiers in Neuroscience·Ricardo Gómez-NietoDolores E López
Nov 12, 2014·Frontiers in Neurology·Benjamin D AuerbachRichard J Salvi
Apr 14, 2016·The Journal of Comparative Neurology·Matthew A SmithSamuel D Crish
Nov 9, 2016·Frontiers in Behavioral Neuroscience·Ryan J Longenecker, Alexander V Galazyuk
Jan 29, 2008·Neuroscience·M E RubioD K Ryugo
Sep 26, 2006·The Journal of Comparative Neurology·David R SerwanskiAngel L De Blas
Jul 22, 2014·The Journal of Comparative Neurology·María E RubioRyuichi Shigemoto
Jul 10, 2021·Frontiers in Synaptic Neuroscience·Chun-Jen Hsiao, Alexander V Galazyuk

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