Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

Archives of Toxicology
Marian ValkoKamil Musílek

Abstract

Transition metal ions are key elements of various biological processes ranging from oxygen formation to hypoxia sensing, and therefore, their homeostasis is maintained within strict limits through tightly regulated mechanisms of uptake, storage and secretion. The breakdown of metal ion homeostasis can lead to an uncontrolled formation of reactive oxygen species, ROS (via the Fenton reaction, which produces hydroxyl radicals), and reactive nitrogen species, RNS, which may cause oxidative damage to biological macromolecules such as DNA, proteins and lipids. An imbalance between the formation of free radicals and their elimination by antioxidant defense systems is termed oxidative stress. Most vulnerable to free radical attack is the cell membrane which may undergo enhanced lipid peroxidation, finally producing mutagenic and carcinogenic malondialdehyde and 4-hydroxynonenal and other exocyclic DNA adducts. While redox-active iron (Fe) and copper (Cu) undergo redox-cycling reactions, for a second group of redox-inactive metals such as arsenic (As) and cadmium (Cd), the primary route for their toxicity is depletion of glutathione and bonding to sulfhydryl groups of proteins. While arsenic is known to bind directly to critical thiols...Continue Reading

References

Aug 18, 1978·Langenbecks Archiv für Chirurgie·P SchlagM Betzler
Jan 1, 1991·Free Radical Biology & Medicine·H EsterbauerH Zollner
Jan 1, 1990·Methods in Enzymology·B Halliwell, J M Gutteridge
Jan 1, 1990·Free Radical Biology & Medicine·C F Babbs
Jan 1, 1990·Free Radical Biology & Medicine·T M Bray, W J Bettger
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M K ShigenagaB N Ames
Jun 1, 1986·The Journal of Nutrition·T M BrayW J Bettger
Aug 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·G S ShuklaS V Chandra
Jun 13, 1981·Lancet·J L Sullivan
Aug 1, 1984·Seminars in Liver Disease·B R Bacon, A S Tavill
Sep 1, 1983·Cancer·E J MargaliothM Chevion
Apr 1, 1981·Cancer·B F IssellG P Bodey
Jan 1, 1980·The American Journal of Clinical Nutrition·J F SullivanR E Burch
Feb 1, 1995·Free Radical Biology & Medicine·S J Stohs, D Bagchi
Dec 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P Holvoet, D Collen
Jan 1, 1994·Free Radical Biology & Medicine·S I Liochev, I Fridovich
Apr 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·C J ChenT Y Tai
Feb 1, 1996·American Journal of Public Health·L T StaynerR A Lemen
Jan 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D Dreher, A F Junod
Jun 1, 1996·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·S Loft, H E Poulsen
Sep 1, 1996·Free Radical Research·B Tadolini, G Hakim
Jan 1, 1996·Free Radical Biology & Medicine·S Toyokuni
Dec 1, 1996·Toxicology Letters·R KumarP K Seth
Jan 1, 1997·Free Radical Biology & Medicine·R V LloydR P Mason
Feb 1, 1997·Drug Metabolism Reviews·C D Klaassen, J Liu
Jun 1, 1997·Toxicology and Applied Pharmacology·D Beyersmann, S Hechtenberg
Jan 13, 1998·Biochimica Et Biophysica Acta·K S Kolibaba, B J Druker
Jun 19, 1998·Current Opinion in Structural Biology·G Dodson, D Steiner
Aug 15, 1998·Molecular and Cellular Endocrinology·D S DarlingB Zhu
May 26, 1999·Southern Medical Journal·J Y Barbee, T S Prince
Sep 2, 1999·Analytical Biochemistry·I GosriwatanaR C Hider
Jan 6, 2000·Archives of Biochemistry and Biophysics·D Touati
Jan 12, 2000·Journal of Biochemical and Molecular Toxicology·L E Rikans, T Yamano

❮ Previous
Next ❯

Citations

Jan 26, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Warut PoontaweeOrawan Wongmekiat
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Catherine PenningtonElizabeth Coulthard
Apr 16, 2016·Journal of Huntington's Disease·Kiersten L BerggrenJonathan H Fox
Oct 30, 2016·Journal of Pharmacological and Toxicological Methods·Ana Paula TerrassoCatarina Brito
Oct 31, 2016·International Journal of Hygiene and Environmental Health·Weiye WangSung Kyun Park
Jan 22, 2017·Analytical and Bioanalytical Chemistry·Fobang LiuChristopher J Kampf
May 31, 2017·Environment International·Maria Grau-PerezMaria Tellez-Plaza
Aug 18, 2016·Angewandte Chemie·Ksenia S Egorova, Valentine P Ananikov
Jul 1, 2017·Bioscience, Biotechnology, and Biochemistry·Hongying DiaoZhuoran Li
Jun 29, 2017·Journal of Agricultural and Food Chemistry·Jie WeiZhiquan Zhou
Apr 4, 2017·Redox Report : Communications in Free Radical Research·Ademola Adetokunbo OyagbemiMomoh Audu Yakubu
Jan 23, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Orawan WongmekiatAnongporn Kobroob
Feb 15, 2018·Nutrients·Raúl DomínguezAlberto Pérez-López
Jan 4, 2018·Nutrients·Pei-Hui LinJianjie Ma
Jan 13, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Catherine C BellMagnus Ingelman-Sundberg
Nov 12, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Yuichi BabaTakashi Matsui
Nov 23, 2017·Frontiers in Genetics·Thomas J S Merritt, Adam J Bewick
Aug 14, 2018·Environmental Health Perspectives·Weiye WangSung Kyun Park
Sep 28, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kathrin ChamaonChristoph H Lohmann
Mar 12, 2018·Biological Trace Element Research·Joaquim RoviraJosé L Domingo
Aug 26, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Zeina SalloumIsabelle Catelas
Oct 24, 2018·Biological Chemistry·Elena ObradorJosé M Estrela
Nov 30, 2018·American Journal of Physiology. Cell Physiology·Amilcare BarcaTiziano Verri
Mar 3, 2018·Cell Death & Disease·Sahar SheykhansariAjay Vikram Singh
Sep 12, 2018·Journal of the Chinese Medical Association : JCMA·Amara GulFarah Mehmood
Mar 29, 2019·Archives of Pharmacal Research·Dong-Hoon Hyun
May 10, 2019·Journal of Leukocyte Biology·Yulia Y TyurinaValerian E Kagan
May 31, 2019·Chemical Communications : Chem Comm·Carlos Sanchez-CanoPeter J Sadler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

© 2021 Meta ULC. All rights reserved