Redox-active biflavonoids from Garcinia brasiliensis as inhibitors of neutrophil oxidative burst and human erythrocyte membrane damage

Journal of Ethnopharmacology
Phanuel Saroni ArwaDulce Helena Siqueira Silva

Abstract

Garcinia brasiliensis, a plant native to the Brazilian Amazon Rainforest, is used in traditional medicine to treat inflammation of the urinary tract, peptic ulcers, arthritis and other conditions. The purposes of this study were to analyze the chemical constituents of G. brasiliensis branches and leaves and to evaluate the potential of isolated compounds to act as inhibitors of both the oxidative burst of stimulated neutrophils and oxidative damage in human erythrocyte membranes to verify the antioxidant and anti-inflammatory effects of this plant. Neutrophils were isolated from the blood of healthy donors by Ficoll-Paque density gradient centrifugation. Superoxide anion and total reactive oxygen species (ROS) produced by stimulated neutrophils were measured by WST-1 reduction and luminol-enhanced chemiluminescence assays, respectively. Radical-induced lipoperoxidation and hemolysis were performed using erythrocytes from the blood of healthy donors. Compounds were isolated from G. brasiliensis branches and leaves by HPLC microfractionation, and structure elucidation of the isolated compounds was performed based on NMR and HR-MS analyses. The biflavonoids procyanidin, fukugetin, amentoflavone and podocarpusflavone isolated from ...Continue Reading

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Citations

Mar 5, 2016·North American Journal of Medical Sciences·Ezekiel Uba Nwose
Jun 1, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Badrinathan SridharanPragasam Viswanathan
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