Redox behaviour of cysteine in the presence of ammonium trioxovanadate(V)

Bioelectrochemistry
S Cakir, E Biçer

Abstract

The interaction of ammonium trioxovanadate(V) with cysteine in aqueous solution was studied by cyclic voltammetry and absorption spectroscopy techniques. In the absence of cysteine, the cyclic voltammogram (CV) of ammonium trioxovanadate(V) solution in 0.1 M phosphate buffer (pH 7) gave two peaks at -0.130 V (reversible) and -0.400 V (irreversible). These peaks (-0.130 V, -0.400 V) can be attributed to V(V)/V(IV) and V(IV)/V(III) redox processes, respectively. In the presence of cysteine at low scan rate (40 mV/s), the peak at -0.780 V, which is assigned to the irreversible reduction of free cystine, was observed. In addition, the reduction peak of the disulfidic anion S(2)(2-) was seen at -0.650 V. Under aerobic conditions, the peaks of the disulfidic anion S(2)(2-) and free cystine are well separated. From electronic spectra of ammonium trioxovanadate(V) and cysteine mixtures, LMCT transition associated with V(V)-cyteine complex was obtained at 743 nm. The stoichiometry (ML(2)) and stability constant (log beta(1:2)=6.67) of V(V)-cysteine complex were determined by means of mole ratio method.

References

May 15, 1989·Archives of Biochemistry and Biophysics·R J KellerL H Piette
Dec 15, 1986·The Biochemical Journal·L G Forni, R L Willson
Dec 26, 1973·Journal of the American Chemical Society·R N LindquistG E Lienhard
Jun 25, 1998·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·E G FerrerE J Baran

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Citations

Jun 22, 2005·Bioelectrochemistry·Semiha Cakir, Ender Biçer
Sep 24, 2009·Memórias do Instituto Oswaldo Cruz·Sergio Sosa-EstaniElsa Leonor Segura
Aug 17, 2018·Expert Review of Clinical Pharmacology·Jadel Müller KratzSergio Sosa-Estani

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