Redox control and oxidative stress in yeast cells

Biochimica Et Biophysica Acta
Enrique HerreroElisa Cabiscol

Abstract

Protein structure and function can be altered by reactive oxygen species produced either by cell metabolism or by external oxidants. Although catalases, superoxide dismutases and peroxidases contribute to maintaining non-toxic levels of reactive oxygen species, modification of amino acid side chains occurs. In particular, oxidative modification of sulphydryl groups in proteins can be a two-faceted process: it could lead to impairment of protein function or, depending on the redox state of cysteine residues, may activate specific pathways involved in regulating key cell functions. In yeast cells, the thioredoxin and glutaredoxin systems participate in such redox regulation in different cell compartments, and interplay exists between both systems. In this context, glutaredoxins with monothiol activity initially characterised in Saccharomyces cerevisiae may display specific regulatory functions at the mitochondria and nuclei. Furthermore, their structural conservation in other organisms point to a conserved important role in metal homeostasis also in higher eukaryotes. Control of gene expression in response to oxidative stress is mediated by several transcription factors, among which Yap1 has a predominant role in S. cerevisiae (P...Continue Reading

References

May 15, 1976·The Biochemical Journal·A BoverisA O Stoppani
Sep 15, 1988·Biochemical and Biophysical Research Communications·K MukaiK Ishizu
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A P van LoonG Schatz
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B N AmesP Hochstein
Jan 1, 1995·Annual Review of Biochemistry·I Fridovich
Mar 15, 1995·Structure·J L Martin
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·A P Schmitt, K McEntee
Jul 5, 1996·Science·R S Sohal, R Weindruch
Feb 1, 1996·Molecular Microbiology·P Moradas-FerreiraW Mager
Feb 1, 1997·Bioscience Reports·J F Turrens
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·J MoskovitzE R Stadtman
Jul 1, 1998·Annual Review of Biophysics and Biomolecular Structure·D BarfordM P Egloff
Aug 26, 1998·The Journal of Biological Chemistry·C GodonJ Labarre
Oct 8, 1998·Biochemistry and Molecular Biology International·R N KanadiaA Botchway
Feb 3, 1999·Annual Review of Genetics·A Rietsch, J Beckwith
May 29, 1999·The Journal of Biological Chemistry·J LeeM B Toledano
Nov 24, 1999·Molecular and Cellular Biology·M T Rodríguez-ManzanequeE Herrero
Nov 24, 1999·Molecular and Cellular Biology·S T ColemanW S Moye-Rowley
Dec 22, 1999·Biochemical Pharmacology·M Zheng, G Storz

❮ Previous
Next ❯

Citations

May 29, 2012·Applied Microbiology and Biotechnology·Hyun-Soo KimWonja Choi
Apr 5, 2013·Applied Microbiology and Biotechnology·Jesús Fierro-RiscoAntonio C Codón
May 7, 2013·Applied Microbiology and Biotechnology·Jidong LiuJian Chen
Apr 18, 2013·Current Microbiology·Rita R PerezEduardo V Soares
Apr 30, 2013·Journal of Bioenergetics and Biomembranes·Yulia DeryabinaNils-Erik L Saris
Apr 13, 2011·Biological Trace Element Research·Bogdan Alexandru StoicaMihai Nechifor
Jan 28, 2009·The Journal of Biological Chemistry·Ikuo SatoNaoki Takaya
Sep 18, 2012·Molecular & Cellular Proteomics : MCP·F-Nora VögtleChris Meisinger
Feb 17, 2010·Antioxidants & Redox Signaling·Renata SantosEmmanuel Lesuisse
Jul 16, 2010·Antioxidants & Redox Signaling·Haike Antelmann, John D Helmann
Nov 8, 2011·Antioxidants & Redox Signaling·Mirko ZaffagniniStéphane D Lemaire
Apr 15, 2011·Molecular Biology of the Cell·Manel DhaouiNaïma Belgareh-Touzé
Feb 11, 2012·Molecular Biology of the Cell·Alex D SheftelRoland Lill
Nov 23, 2012·Molecular Biology of the Cell·Aaron Z WelchDouglas E Koshland
Apr 12, 2012·Journal of Experimental Botany·Fanny RamelIvan Couée
Apr 28, 2009·Eukaryotic Cell·Sadri ZnaidiMartine Raymond
Jan 5, 2010·BMC Genomics·Tim van ZutphenIda J van der Klei
Sep 1, 2009·Microbial Cell Factories·M Isabel González-SisoM Esperanza Cerdán
Nov 11, 2011·PloS One·Nannette Y YountMichael R Yeaman
Oct 31, 2012·International Journal of Molecular Sciences·Johan O WestmanMohammad J Taherzadeh
Dec 19, 2013·Applied Microbiology and Biotechnology·Dao-Qiong ZhengXue-Chang Wu
Aug 29, 2013·Oxidative Medicine and Cellular Longevity·Gianluca Farrugia, Rena Balzan
Mar 6, 2009·Applied Microbiology and Biotechnology·P J VerbelenF R Delvaux
Jun 9, 2014·Applied Biochemistry and Biotechnology·Ayşegül DoğanFikrettin Şahin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.