Redox control of cancer cell destruction

Redox Biology
Csaba HegedűsLászló Virág

Abstract

Redox regulation has been proposed to control various aspects of carcinogenesis, cancer cell growth, metabolism, migration, invasion, metastasis and cancer vascularization. As cancer has many faces, the role of redox control in different cancers and in the numerous cancer-related processes often point in different directions. In this review, we focus on the redox control mechanisms of tumor cell destruction. The review covers the tumor-intrinsic role of oxidants derived from the reduction of oxygen and nitrogen in the control of tumor cell proliferation as well as the roles of oxidants and antioxidant systems in cancer cell death caused by traditional anticancer weapons (chemotherapeutic agents, radiotherapy, photodynamic therapy). Emphasis is also put on the role of oxidants and redox status in the outcome following interactions between cancer cells, cytotoxic lymphocytes and tumor infiltrating macrophages.

Citations

Oct 3, 2018·The Journal of Pathology·Anna MartnerKristoffer Hellstrand
Nov 14, 2018·Chembiochem : a European Journal of Chemical Biology·Nima GharibiAndrew A Beharry
Oct 24, 2018·Biological Chemistry·Elena ObradorJosé M Estrela
Jun 26, 2020·Angewandte Chemie·Mohamed FaresPhilip A Gale
Sep 11, 2019·Nature Communications·Emre BaltaYvonne Samstag
Sep 11, 2019·International Journal of Molecular Sciences·Maria I NardellaFabio Arnesano
Jan 21, 2020·Iranian Journal of Nursing and Midwifery Research·Leila HeydarzadehJavad RasouIi
Sep 22, 2019·International Journal of Molecular Sciences·David L Newman, Stephen L Gregory
Jan 29, 2020·Antioxidants & Redox Signaling·Katarína SmolkováPéter Bai
Jan 24, 2019·Bioinformatics and Biology Insights·Franklyn Nonso IheagwamJelili Oyelade
Apr 12, 2019·Frontiers in Physiology·Cristiane Assunção da Costa Cunha MafraAurigena Antunes de Araújo
Dec 5, 2018·Redox Biology·Bernice Woon Li LeeDerrick Sek Tong Ong
Aug 23, 2020·Free Radical Biology & Medicine·Ignacio A Cortés FuentesJuan G Gormaz
Feb 5, 2021·Antioxidants·Maria-Angeles Bonmati-Carrion, Antonia Tomas-Loba
Dec 15, 2020·Oxidative Medicine and Cellular Longevity·Hanna Grauers WiktorinAnna Martner
Sep 16, 2020·Pathology, Research and Practice·Natália Medeiros Dias LopesAlessandra Lourenço Cecchini
Oct 5, 2020·Redox Biology·Rute A P E CostaAdriana F Paes Leme
May 21, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Elizabeth CampbellAnton V Naumov
Jun 22, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jinzhi XuTong Zhang

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Datasets Mentioned

BETA
U937

Methods Mentioned

BETA
ubiquitination
xenografts
xenograft

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