Redox control of GTPases: from molecular mechanisms to functional significance in health and disease

Antioxidants & Redox Signaling
Jongyun Heo

Abstract

Small GTPases, including the proto-oncoprotein Ras and Rho GTPases, are involved in various cellular signaling events. Some of these small GTPases are redox sensitive, including Ras, Rho, Ran, Dexras1, and Rhes GTPases. Thus, the redox-mediated regulation of these GTPases often determines the course of their cellular signaling cascades. This article takes into consideration the application of Marcus theory to potential redox-based molecular mechanisms in the regulation of these redox-sensitive GTPases and the relevance of such mechanisms to a specific redox-sensitive motif. The discussion also takes into account various diseases, including cancers, heart, and neuronal disorders, that are often linked with the dysregulation of the redox signaling cascades associated with these redox-sensitive GTPases.

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Methods Mentioned

BETA
GTPases
nucleotide-exchange
GTPase
nucleotide exchange
X-ray
circular dichroism
NMR
chemical modification
pull-down

Software Mentioned

RASMOL
MODEL
SWISS

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