Redox control of vascular smooth muscle cell function and plasticity

Laboratory Investigation; a Journal of Technical Methods and Pathology
Brittany G Durgin, Adam C Straub

Abstract

Vascular smooth muscle cells (SMC) play a major role in vascular diseases, such as atherosclerosis and hypertension. It has long been established in vitro that contractile SMC can phenotypically switch to function as proliferative and/or migratory cells in response to stimulation by oxidative stress, growth factors, and inflammatory cytokines. Reactive oxygen species (ROS) are oxidative stressors implicated in driving vascular diseases, shifting cell bioenergetics, and increasing SMC proliferation, migration, and apoptosis. In this review, we summarize our current knowledge of how disruptions to redox balance can functionally change SMC and how this may influence vascular disease pathogenesis. Specifically, we focus on our current understanding of the role of vascular nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) 1, 4, and 5 in SMC function. We also review the evidence implicating mitochondrial fission in SMC phenotypic transitions and mitochondrial fusion in maintenance of SMC homeostasis. Finally, we discuss the importance of the redox regulation of the soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP)-protein kinase G (PKG) pathway as a potential oxidative and therapeutic target for r...Continue Reading

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Citations

Oct 7, 2019·Clinical and Experimental Pharmacology & Physiology·Ying WangXu He
Jul 12, 2019·Experimental & Molecular Medicine·Jinoh KimYun Soo Bae
Feb 14, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Alicia N Lyle, W Robert Taylor
Aug 21, 2019·Frontiers in Cardiovascular Medicine·Denise BurtenshawPaul A Cahill
Aug 25, 2020·Oxidative Medicine and Cellular Longevity·Liangkai ChengCaiyan Wang
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Mar 27, 2021·Vascular Pharmacology·Esteban G FigueroaEmilio A Herrera
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Jul 8, 2021·Journal of Cardiovascular Pharmacology·Yibo LiGuoan Zhao
Jan 14, 2022·Acta Pharmacologica Sinica·Chao YeXiu-Zhen Li

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Methods Mentioned

BETA
GTPase
transgenic

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