Redox cycling in nanofluidic channels using interdigitated electrodes

Analytical and Bioanalytical Chemistry
Edgar D GoluchSerge G Lemay

Abstract

Amperometric detection is ideally suited for integration into micro- and nanofluidic systems as it directly yields an electrical signal and does not necessitate optical components. However, the range of systems to which it can be applied is constrained by the limited sensitivity and specificity of the method. These limitations can be partially alleviated through the use of redox cycling, in which multiple electrodes are employed to repeatedly reduce and oxidize analyte molecules and thereby amplify the detected signal. We have developed an interdigitated electrode device that is encased in a nanofluidic channel to provide a hundred-fold amplification of the amperometric signal from paracetamol. Due to the nanochannel design, the sensor is resistant to interference from molecules undergoing irreversible redox reactions. We demonstrate this selectivity by detecting paracetamol in the presence of excess ascorbic acid.

References

Oct 1, 1985·Brain Research·J A Stamford
Feb 25, 1998·Biosensors & Bioelectronics·F LisdatF W Scheller
Jan 31, 2004·Analytical Chemistry·Eric NeblingRainer Hintsche
Apr 22, 2004·Lab on a Chip·Björan TimmerAlbert van den Berg
Jul 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael L A V HeienR Mark Wightman
Oct 20, 2005·Lab on a Chip·Anthony L GarciaGabriel P López
Nov 9, 2006·Nano Letters·Diego KrapfSerge G Lemay
Feb 15, 2007·Nano Letters·Marcel A G ZevenbergenSerge G Lemay
Feb 10, 1995·Science·F R Fan, A J Bard
Jan 16, 2008·Analytical Chemistry·Bernhard WolfrumSerge Lemay
Feb 6, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Ryan J White, Henry S White
Mar 7, 2008·Analytical Chemistry·Patrick Abgrall, Nam Trung Nguyen
Jun 11, 2008·Journal of the American Chemical Society·Peng Sun, Michael V Mirkin
Sep 3, 2009·Journal of the American Chemical Society·Marcel A G ZevenbergenSerge G Lemay
Sep 12, 2009·Analytical Chemistry·Marcel A G ZevenbergenSerge G Lemay
Apr 11, 2008·Sensors·Nicole Jaffrezic-Renault, Sergei V Dzyadevych

❮ Previous
Next ❯

Citations

Sep 29, 2011·Analytical and Bioanalytical Chemistry·Andreas B DahlinJanos Vörös
Apr 18, 2012·Journal of the American Chemical Society·Sean P BranaganPaul W Bohn
Jul 9, 2014·Annual Review of Analytical Chemistry·Klaus MathwigSerge G Lemay
May 14, 2014·Annual Review of Analytical Chemistry·Karen Dawson, Alan O'Riordan
Jan 13, 2010·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Md Monirul IslamHiroaki Misawa
Jan 13, 2010·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Md Monirul IslamHiroaki Misawa
May 11, 2010·Journal of Electroanalytical Chemistry·Gregory S McCartyMatthew K Zachek
Jun 28, 2017·Faraday Discussions·Zinaida A KostiuchenkoSerge G Lemay
Nov 20, 2013·Nanoscale·Martin HüskeBernhard Wolfrum
Mar 5, 2020·Lab on a Chip·Fumihiro SassaHiroaki Suzuki
Aug 28, 2014·Beilstein Journal of Nanotechnology·Enno KätelhönBernhard Wolfrum
Oct 2, 2014·The Analyst·Sahana SarkarSerge G Lemay
Sep 12, 2009·Analytical Chemistry·Marcel A G ZevenbergenSerge G Lemay
Aug 30, 2011·Analytical Chemistry·Mehdi Rahimi, Susan R Mikkelsen
Aug 7, 2010·Analytical Chemistry·Liza Rassaei, Frank Marken
Apr 23, 2011·Analytical Chemistry·Liza RassaeiSerge G Lemay
Feb 26, 2014·Analytical Chemistry·Rahul R Kamath, Marc J Madou
Dec 26, 2017·ACS Sensors·Ga-Yeon LeeJae-Chul Pyun
Oct 25, 2011·Analytical Chemistry·Christopher Batchelor-McAuleyRichard G Compton
Jul 4, 2017·ACS Sensors·Hamid Reza ZafaraniLiza Rassaei
Jan 10, 2019·Analytical Chemistry·Eka NovianaCharles S Henry
Aug 12, 2014·ACS Nano·Liza RassaeiSerge G Lemay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Chemical Society
Marcel A G ZevenbergenSerge G Lemay
Analytical Chemistry
Marcel A G ZevenbergenSerge G Lemay
Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
P JinH Misawa
© 2021 Meta ULC. All rights reserved