Redox-dependent induction of antioxidant defenses by phenolic diterpenes confers stress tolerance in normal human skin fibroblasts: Insights on replicative senescence

Free Radical Biology & Medicine
Ana C CarvalhoC F Lima

Abstract

Mild stress-induced hormesis represents a promising strategy for targeting the age-related accumulation of molecular damage and, therefore, for preventing diseases and achieving healthy aging. Fruits, vegetables, and spices contain a wide variety of hormetic phytochemicals, which may explain the beneficial health effects associated with the consumption of these dietary components. In the present study, the induction of cellular antioxidant defenses by the phenolic diterpenes carnosic acid (CA) and carnosol (CS) were studied in normal human skin fibroblasts, and insights into the aging process at the cellular level investigated. We observed that CA and CS induced several cytoprotective enzymes and antioxidant defenses in human fibroblasts, whose induction was dependent on the cellular redox state for CS and associated with Nrf2 signaling for both compounds. The stress response elicited by preincubation with CS conferred a cytoprotective action against a following oxidant challenge with tert-butyl hydroperoxide, confirming its hormetic effect. Preincubation of normal fibroblasts with CS also protected against hydrogen peroxide-induced premature senescence. Furthermore, cultivation of middle passage normal human skin fibroblasts i...Continue Reading

References

Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·V J CristofaloJ C Beck
Feb 14, 2004·The Journal of Biological Chemistry·Carmen Martin-RuizThomas von Zglinicki
Feb 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jung H SuhTory M Hagen
Aug 12, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Suresh I S Rattan
Nov 3, 2004·Trends in Molecular Medicine·Hozumi Motohashi, Masayuki Yamamoto
Feb 15, 2005·Journal of Ethnopharmacology·Cristovao F LimaCristina Pereira-Wilson
Jun 14, 2005·Cancer Cell·Goberdhan P Dimri
Jan 31, 2006·Aging Cell·Mark A WilsonCatherine A Wolkow
Feb 8, 2006·Current Biology : CB·Dario R ValenzanoAlessandro Cellerino
Jun 29, 2006·Annals of the New York Academy of Sciences·David Christian KraftSuresh I S Rattan
Jun 29, 2006·Annals of the New York Academy of Sciences·Elise R NielsenSuresh I S Rattan
Jul 22, 2006·Life Sciences·Cristovao F LimaCristina Pereira-Wilson
Aug 5, 2006·Advances in Enzyme Regulation·Makoto Kobayashi, Masayuki Yamamoto
Sep 18, 2007·Ageing Research Reviews·Zsolt RadakSataro Goto
Oct 5, 2007·Ageing Research Reviews·Mark P Mattson
Oct 30, 2007·Ageing Research Reviews·Suresh I S Rattan
Dec 29, 2007·Ageing Research Reviews·Mark P Mattson
Jan 16, 2008·Developmental Cell·Gerasimos P Sykiotis, Dirk Bohmann
Jun 11, 2008·Neuromolecular Medicine·Tae Gen SonMark P Mattson
Jun 21, 2008·American Journal of Respiratory Cell and Molecular Biology·Masaru SuzukiMasaharu Nishimura
Jul 26, 2008·Advanced Drug Delivery Reviews·Igor Rebrin, Rajindar S Sohal
Sep 30, 2008·The Journal of Biological Chemistry·Fan ZhangFrank M Torti
Jan 27, 2009·Biological Chemistry·Nazzareno BallatoriChristine L Hammond
Apr 4, 2009·Dose-response : a Publication of International Hormesis Society·Suresh I S RattanCristovao F Lima
May 8, 2009·Cellular and Molecular Life Sciences : CMLS·Eun Seong HwangHyun Tae Kang
Feb 2, 2010·Toxicology and Applied Pharmacology·Kai-Cheng LianYung-Wei Sun
Oct 30, 2010·Integrative and Comparative Biology·Kaitlyn N LewisRochelle Buffenstein
Nov 24, 2011·Biochimica Et Biophysica Acta·Vittorio CalabreseEdward J Calabrese
Apr 17, 2012·Seminars in Cell & Developmental Biology·Hongqiao Zhang, Henry Jay Forman
Apr 19, 2012·Expert Opinion on Drug Discovery·Suresh I S Rattan
Apr 25, 2012·Experimental Gerontology·Dino Demirovic, Suresh I S Rattan

❮ Previous
Next ❯

Citations

Jun 17, 2016·Phytotherapy Research : PTR·Md Torequl IslamAna Amélia de Carvalho Melo-Cavalcante
Oct 22, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Sagrario Martín-AragónPaloma Bermejo-Bescós
Oct 8, 2016·Scientific Reports·Lorenzo Di Cesare MannelliCarla Ghelardini
May 4, 2017·Antioxidants & Redox Signaling·Luis Ángel Maciel-BarónMina Königsberg
Jan 26, 2018·Basic & Clinical Pharmacology & Toxicology·Geir BjørklundRoman Lysiuk
Apr 4, 2017·Phytotherapy Research : PTR·Muhammad Torequl Islam
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberta HoskinMary Ann Lila

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.