Redox Dichotomy in Cell Fate Decision: Evasive Mechanism or Achilles Heel?

Antioxidants & Redox Signaling
Shazib Pervaiz

Abstract

Cellular redox state is a consequence of the balance between the rates of reactive oxygen species and/or reactive nitrogen species, and their dissipation via enzymatic and nonenzymatic redox buffering systems. While low levels of oscillation are associated with normal cellular metabolism, stimuli that favor a significant shift in the redox microenvironment, through either the increased production and/or compromise of the antioxidant defenses, induce overt oxidative stress. This change in the redox set point triggers a host of cellular responses ranging from modifications in cellular macromolecules, organelle morphology and physiology, amplified cell-to-cell and intracellular signaling, and changes in genome, epigenome, and proteome. The consequence of this dysregulated cellular homeostasis is therefore manifested in the form of a plethora of pathological states such as inflammation, diabetes mellitus, neurodegenerative disorders, atherosclerosis, and cancer. On the backdrop of these observations, this Forum attempts at reviewing the current understanding of how a prooxidant intracellular milieu favors cell survival while overt oxidative stress results in death execution, and the translation of these biological effects in human ...Continue Reading

References

May 29, 2007·The International Journal of Biochemistry & Cell Biology·Shazib Pervaiz, Marie-Veronique Clement
Aug 18, 2017·Antioxidants & Redox Signaling·Akshay V BhatReshma Taneja
Aug 25, 2017·Antioxidants & Redox Signaling·Yulia Y TyurinaValerian E Kagan
Dec 8, 2017·Antioxidants & Redox Signaling·Svetlana N Radyuk, William C Orr
Jan 7, 2018·Antioxidants & Redox Signaling·Sebastian Öther-Gee PohlShazib Pervaiz
Jan 13, 2018·Antioxidants & Redox Signaling·Luksana ChaiswingDaret K St Clair

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Citations

May 3, 2020·Cellular and Molecular Life Sciences : CMLS·Anuradha KirtoniaManoj Garg
Jun 20, 2020·Molecular Cell·Saverio MarchiPaolo Pinton
Jul 22, 2021·The FEBS Journal·Ling WuLiang Zhao

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Methods Mentioned

BETA
GTPase

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