Redox-guided small molecule antimycobacterials

IUBMB Life
Amogh KulkarniHarinath Chakrapani

Abstract

The emergence of drug resistance has posed a major challenge to treatment of tuberculosis worldwide. The new drug candidates in the pipeline are few and therefore there is an urgent need to develop antimycobacterials with novel mechanisms of action. Maintenance of redox homeostasis is integral to mycobacterial survival and growth. Therefore, perturbation of this equilibrium can result in irreversible stress induction and inhibition of growth. Herein, we review a number of small molecules that have either been designed to induce redox stress or were found to do so after their discovery. A number of these small molecules are quite effective against drug-resistant mycobacterial strains and thus offer scope for exploration of potentially new mechanism of action. The progress in redox-guided antimycobacterial compounds and the challenges towards clinical applications are reviewed. © 2018 IUBMB Life, 70(9):826-835, 2018.

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Citations

Aug 19, 2018·IUBMB Life·Amit Singh, Avadhesha Surolia
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kamal DuaPhilip M Hansbro
Apr 20, 2021·ACS Omega·Vallabhaneni S MurthyVijayaparthasarathi Vijayakumar

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