Redox homeostasis, T cells and kidney diseases: three faces in the dark

Clinical Kidney Journal
Luca SimeoniAndreas Linkermann

Abstract

The redox equilibrium is crucial for the maintenance of immune homeostasis. Here, we summarize recent data showing that oxidation regulates T-cell functions and that alterations of the redox equilibrium may play an important role in the pathogenesis of inflammatory conditions affecting the kidneys. We further discuss potential links between oxidation, T cells and renal diseases such as systemic lupus erythematosus, renal ischaemia/reperfusion injury, end-stage renal disease and hypertension. The basic understanding of oxidation as a means by which diseases are directly affected results in unexpected pathophysiological similarities. Finally, we describe potential therapeutic options targeting redox systems for the treatment of nephropathies affecting humans.

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Citations

Apr 4, 2019·American Journal of Physiology. Renal Physiology·Venkateswara Reddy GogulamudiKailash N Pandey
May 4, 2017·Immunological Reviews·Wulf Tonnus, Andreas Linkermann
Feb 8, 2018·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Maria ChiriacoAndrea Finocchi

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