Redox Imbalance in Idiopathic Pulmonary Fibrosis: A Role for Oxidant Cross-Talk Between NADPH Oxidase Enzymes and Mitochondria

Antioxidants & Redox Signaling
Carmen VeithAlbert van der Vliet

Abstract

Significance: Idiopathic pulmonary fibrosis (IPF) is a progressive age-related lung disease with a median survival of only 3 years after diagnosis. The pathogenic mechanisms behind IPF are not clearly understood, and current therapeutic approaches have not been successful in improving disease outcomes. Recent Advances: IPF is characterized by increased production of reactive oxygen species (ROS), primarily by NADPH oxidases (NOXes) and mitochondria, as well as altered antioxidant defenses. Recent studies have identified the NOX isoform NOX4 as a key player in various important aspects of IPF pathology. In addition, mitochondrial dysfunction is thought to enhance pathological features of IPF, in part by increasing mitochondrial ROS (mtROS) production and altering cellular metabolism. Recent findings indicate reciprocal interactions between NOX enzymes and mitochondria, which affect regulation of NOX activity as well as mitochondrial function and mtROS production, and collectively promote epithelial injury and profibrotic signaling. Critical Issues and Future Directions: The precise molecular mechanisms by which ROS from NOX or mitochondria contribute to IPF pathology are not known. This review summarizes the current knowled...Continue Reading

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Citations

Apr 3, 2020·The Journal of International Medical Research·Shiwen KeLiangji Liu
May 24, 2020·Antioxidants & Redox Signaling·Giuseppe ValacchiPablo Evelson
May 16, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Vidyani SuryadevaraViswanathan Natarajan
Dec 19, 2019·Frontiers in Physiology·Kristiana RoodSean M Wilson
Feb 2, 2021·Reproductive Sciences·Philippe VangriekenAlex H V Remels
Jan 19, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Mengran XuXin Sun
Dec 17, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carmen VeithAlbert van der Vliet
Apr 4, 2021·Journal of Clinical Medicine·María MagallónFrancisco Dasí
Aug 7, 2021·Oxidative Medicine and Cellular Longevity·Wen-Cheng ZhouHong-Wei Yao
Aug 28, 2021·International Journal of Molecular Sciences·Jooyeon LeeSe-Ran Yang
Sep 1, 2021·Molecular and Cellular Biochemistry·Edilburga Reyes-JiménezVerónica Rocío Vásquez-Garzón

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Methods Mentioned

BETA
bronchoalveolar lavage
AECs

Clinical Trials Mentioned

NCT02874989

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