Redox Imbalance in Lung Cancer of Patients with Underlying Chronic Respiratory Conditions

Molecular Medicine
Mercè Mateu-JimenezE Barreiro

Abstract

Chronic respiratory diseases such as obstructive pulmonary disease (COPD) and oxidative stress may underlie lung cancer (LC). We hypothesized that the profile of oxidative and antioxidant events may differ in lung tumors and blood compartments of patients with non-small cell LC (NSCLC) with and without COPD. Redox markers (immunoblotting, ELISA, chemiluminescence, 2D electrophoresis and proteomics) were analyzed in blood samples of 17 control subjects and 80 LC patients (59 LC-COPD and 21 LC) and lung specimens (tumor and nontumor) from those undergoing thoracotomy (35 patients: 23 LC-COPD and 12 LC). As smoking history was more prevalent in LC-COPD patients, these were further analyzed post hoc as heavy and moderate smokers (cutoff, 60 pack-years). Malondialdehyde (MDA)-protein adducts and SOD1 levels were higher in tumor and nontumor samples of LC-COPD than in LC. In tumors compared with nontumors, SOD2 protein content was greater, whereas catalase levels were decreased in both LC and LC-COPD patients. Blood superoxide anion levels, protein carbonylation and nitration were greater in LC and LC-COPD patients than in the controls, and in the latter patients compared with the former. Systemic superoxide anion, protein carbonyls ...Continue Reading

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Citations

Oct 30, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Mercè Mateu-JimenezEsther Barreiro
Mar 23, 2017·BMC Complementary and Alternative Medicine·Xiao YangJinhua Shen
Apr 27, 2018·European Clinical Respiratory Journal·M KentsonH L Persson
Jan 27, 2018·Clinical Epigenetics·Mercè Mateu-JimenezEsther Barreiro
Dec 13, 2019·Expert Review of Proteomics·David Sheehan, Brian McDonagh
Mar 28, 2017·Journal of Translational Medicine·Hai-Xing ZhuJie-Bai Zhou
Nov 14, 2017·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Osamu ArakiMasayuki Chida
Jul 13, 2017·Oxidative Medicine and Cellular Longevity·Ilaria MarroccoIlaria Peluso
Jul 28, 2020·Redox Biology·Álvaro Viedma-PoyatosDolores Pérez-Sala

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