Redox, immune and genetic biomarker system for personalized treatments in colorectal cancer

World Journal of Gastrointestinal Oncology
A M BerghellaP Pellegrini

Abstract

Identifying biomarkers for the risk of developing degenerative processes linked to aging and colorectal cancer (CRC) onset that could improve clinical strategies. To determine valid targets and a predictive biomarker's system of chronicization of inflammation for cancer treatment. A group of 147 CRC patients was studied. Clinical diagnosis was confirmed histopathologically, and patients were sub-typed using the pathological tumor-node-metastasis classification. Thirteen colon adenoma patients and 219 healthy subjects were also studied. A system biology study on Thioredoxin1/CD30 redox-immune systems (Trx1/CD30), T helper cytokines and polymorphisms of killer immunoglobulin-like receptors, FcγRIIa-131H/R and FcγRIIIa-158V/F was carried out. Enzyme-linked immunosorbent assay was performed to analyze sera. Genetic study was executed by polymerase chain reaction sequence-specific primers and sequence-based typing method. Statistical analysis was performed by using the "Statgraphics software systems". We found a positive increase between Trx1/RTrx1 levels and sCD30 level and increased age. With respect to the gender relationships, there were distinct differences. Females showed a primary relationship between transforming growth fact...Continue Reading

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Methods Mentioned

BETA
hormone replacement therapy
electrophoresis
genotyping
PCR
PCA

Software Mentioned

Diagnostic
MedCalc
Statistical Graphics
Statgraphics software

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