Redox modulation of Ca2+ signaling in human endothelial and smooth muscle cells in pre-eclampsia.

Antioxidants & Redox Signaling
Joern R SteinertGiovanni E Mann

Abstract

Pre-eclampsia (PE) is a leading cause of maternal hypertension in pregnancy and is associated with fetal growth restriction, premature birth, and fetal and maternal mortality. Activation and dysfunction of the maternal and fetal endothelium in PE appears to be a consequence of increased oxidative stress, resulting from elevated levels of circulating lipid peroxides. Accumulating evidence implicates reactive oxygen species (ROS) in the pathogenesis of vascular dysfunction in PE, perhaps involving a disturbance in intracellular Ca(2+) signaling. Several ion-transport pathways are highly sensitive to oxidative stress, and the resulting modulation of ion transport by ROS will affect intracellular Ca(2+) homeostasis. We review the evidence that changes in ion transport induced by ROS may be linked with abnormalities in Ca(2+)-mediated signal transduction, leading to endothelial and smooth muscle dysfunction in maternal and fetal circulations in PE. As dysregulation of Ca(2+) signaling in fetal umbilical endothelial cells is maintained in culture and embryonic, fetal, and postnatal development is affected by the cellular redox state, we hypothesize that impaired redox signaling in PE may influence "programming" of the fetal cardiovas...Continue Reading

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Citations

Apr 12, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Adriana M L PimentelAngela C Resende
Sep 15, 2010·Free Radical Research·Anne Negre-SalvayreNeven Zarkovic
Aug 19, 2015·Free Radical Biology & Medicine·Sarah J ChappleGiovanni E Mann
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Feb 1, 2011·Free Radical Biology & Medicine·Chao-Nin WangTzu-Hao Wang
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Jul 18, 2017·BioMed Research International·Nahed El-NajjarKhaled Machaca
Jul 8, 2020·International Journal of Molecular Sciences·María F Rozas-VillanuevaMauricio A Retamal

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