Redox Pioneer: Professor Sue Goo Rhee.

Antioxidants & Redox Signaling
Rodney L Levine, P Boon Chock

Abstract

Dr. Sue Goo Rhee is recognized as a Redox Pioneer because he has published five articles in the field of antioxidants and redox signaling that have been cited >1000 times and 69 of his articles in this field have been cited between 100 and 1000 times. Dr. Rhee is known for his discovery of the first three prototypical members of the phospholipase C family, and for the discovery of the ubiquitously expressed peroxiredoxins. Peroxiredoxin catalyzes the thiol-mediated reduction of H2O2. These enzymes protect cellular molecules from oxidative damage. Importantly, they also regulate cell signaling by modulating the intracellular levels of H2O2 that are induced by signaling agonists. He elucidated the mechanism by which the peroxiredoxins participate in signaling by H2O2: Dr. Rhee demonstrated that growth agonists such as epidermal growth factor induce a transient elevation of intracellular H2O2 that oxidize the catalytically essential cysteine residue of protein tyrosine phosphatases. The oxidation inactivates the phosphatases, allowing enhanced protein tyrosine phosphorylation to mediate cell signaling. In addition, he established that peroxiredoxins are exquisitely regulated through phosphorylation, glutathionylation, and hyperoxi...Continue Reading

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S G RheeE R Stadtman
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R L LevineE R Stadtman
May 20, 1998·Nature Structural Biology·H J ChoiS E Ryu
Jul 20, 1999·Experimental & Molecular Medicine·S G Rhee
Jun 8, 2001·Annual Review of Biochemistry·S G Rhee
Oct 5, 2001·The Journal of Biological Chemistry·E R Stadtman
Dec 26, 2001·Science's STKE : Signal Transduction Knowledge Environment·S G RheeJ Kwon
Apr 26, 2003·Science·Zachary A WoodP Andrew Karplus
Nov 11, 2003·The Journal of Biological Chemistry·Woojin JeongSue Goo Rhee
Nov 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jaeyul KwonSue Goo Rhee
Dec 14, 2004·The Journal of Biological Chemistry·Hyun Ae WooSue Goo Rhee
Dec 31, 2008·Antioxidants & Redox Signaling·Hyun Ae WooSue Goo Rhee
Oct 26, 2010·Antioxidants & Redox Signaling·Andrea HallP Andrew Karplus
Jan 29, 2011·Nature·John S O'Neill, Akhilesh B Reddy
Jan 29, 2011·Nature·John S O'NeillAndrew J Millar
Jul 16, 2013·Methods in Enzymology·Christine C Winterbourn
Aug 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Chun-Seok ChoSue Goo Rhee
Jul 8, 2015·The Journal of Cell Biology·Jung Mi LimSue Goo Rhee
Aug 4, 2015·Molecular Cell·In Sup KilSue Goo Rhee
Feb 23, 2017·Annual Review of Biochemistry·Sue Goo Rhee, In Sup Kil
Jun 8, 2017·Antioxidants & Redox Signaling·Sue Goo RheeDongmin Kang

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