PMID: 9523768Apr 2, 1998Paper

Redox potential measurements of plasma in patients undergoing coronary artery bypass graft and its clinical significance

Journal of Pharmacological and Toxicological Methods
S K RaoP S Rao

Abstract

The apparent redox potentials (Em) of plasma as a marker of oxidant injury during coronary artery bypass graft (CABG) is determined, and their clinical significance is discussed. We measured plasma Em of normal volunteers (n = 20) and samples drawn at different time points from patients undergoing elective CABG (n = 60) directly and by adding 5 microl (20 mM) oxidants or reductants with known redox potential to plasma (95 microl), using a micro Pt/AgCl combination redox electrode. The Em value stays elevated up to 30 min during the surgery, after the administration of protamine it came down toward a more reduced state. Similar changes are seen with the lactate pyruvate ratio. Smaller changes of Em than normal are observed in plasma samples from patients treated with Aprotinin (antiprotease), Carmeda (heparin-coated) circuit and aspirin reflecting their protective effect. Redox potential (Em) measurements appear to be effective and useful in monitoring redox shifts wherever oxidative stress needs to be monitored.

References

Sep 23, 1977·Biochemical and Biophysical Research Communications·P S RaoH S Mueller
May 1, 1992·Chemico-biological Interactions·J J HagemanN P Vermeulen
Oct 15, 1992·Experientia·M JellinekA E Baue
Apr 1, 1987·Journal of Pharmacological Methods·J D RouillonP Magnin
Sep 1, 1972·The Journal of Surgical Research·H M Shapiro
Feb 1, 1995·Journal of Cardiothoracic and Vascular Anesthesia·J M AlvarezR Wilson
May 1, 1996·Molecular and Chemical Neuropathology·M A PappollaK Sambamurti
Sep 30, 1996·Annals of the New York Academy of Sciences·P S RaoJ R Cohen
Dec 1, 1996·Neurology·P Jenner, C W Olanow
Mar 1, 1997·The Keio Journal of Medicine·D Jourd'heuilM B Grisham

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Citations

Aug 29, 2012·Pulmonary Pharmacology & Therapeutics·Amsel M SioreKenneth L Brigham
Jul 21, 2011·Acta Anaesthesiologica Scandinavica·P PignatelliG Delogu
Jul 31, 2007·Biochemical and Biophysical Research Communications·Leonard T RaelDavid Bar-Or
Jul 18, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Bruno Coêlho CavalcantiManoel Odorico de Moraes

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