Redox-Reactive Field-Effect Transistor Nanodevices for the Direct Monitoring of Small Metabolites in Biofluids toward Implantable Nanosensors Arrays

ACS Nano
Vadim KrivitskyFernando Patolsky

Abstract

Chemically modified field-effect transistor (FET) nanodevices were shown to be a selective and extremely sensitive detection platform. In FET-based sensors, signal amplification and transduction is based on electrostatic gating of the nanometric semiconductor channel by analyte-receptor interactions, which measurably affect the transconductance of the device. However, chemically modified FETs must overcome several fundamental limitations before they can be effectively deployed as real-time sensors for bioevents occurring on their surface in complex biofluids. Here, we demonstrate the development of amperoFET devices for the real-time continuous monitoring of small molecular metabolites in biofluids. The surface of the nanowires is covalently modified with a redox reversible moiety, which is easily oxidized in the presence of H2O2. The reversible redox transformation of the surface-confined molecules is carried out by a hot electron injection mechanism, conducted simply by the modulation of the source-drain current through the nanoFET sensing device. By this approach, electrons may be injected by the nanowire element into the surface-confined redox moiety and thus maintain a whole-electrically actuated redox system in which the ...Continue Reading

References

Nov 15, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·V J Thannickal, B L Fanburg
Sep 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fernando PatolskyCharles M Lieber
May 14, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kewal K Jain
Sep 20, 2005·Nature Biotechnology·Gengfeng ZhengCharles M Lieber
Jul 22, 2006·Analytical Chemistry·Fernando PatolskyCharles M Lieber
Apr 27, 2007·Nature·Thomas P BurgScott R Manalis
Mar 5, 2010·Nano Letters·Alexander PevznerFernando Patolsky
Aug 18, 2010·Angewandte Chemie·Yoni EngelFernando Patolsky
Apr 19, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Garry M SteilMichael S D Agus
Aug 6, 2011·Journal of the American Chemical Society·Aleksandar VacicMark A Reed
Nov 17, 2011·Journal of the American Chemical Society·Moria KwiatFernando Patolsky
Jan 10, 2012·The Journal of Clinical Endocrinology and Metabolism·Guillermo E UmpierrezUNKNOWN Endocrine Society
Apr 18, 2012·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Patricia CasalStephen C Lee
Jun 25, 2014·Nature Communications·Amir LichtensteinFernando Patolsky
May 14, 2016·Archives of Biochemistry and Biophysics·Henry Jay FormanKelvin J A Davies

❮ Previous
Next ❯

Citations

May 26, 2020·Journal of Nanobiotechnology·Ella Yeor-DavidiFernando Patolsky
Mar 2, 2021·ACS Applied Materials & Interfaces·Kyooho JungXiuling Li
Nov 28, 2020·Analytical Chemistry·Joshua M ZieglerReginald M Penner
Aug 28, 2020·Analytical Chemistry·Reut MeirFernando Patolsky

❮ Previous
Next ❯

Methods Mentioned

BETA
biosensing
biosensors
chip
X-ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.