Redox regulation in malaria: current concepts and pharmacotherapeutic implications

Current Medicinal Chemistry
Manish GoyalUday Bandyopadhyay

Abstract

Malaria imposes a serious threat to human and becomes more prevalent due to the emergence of drug resistant parasite. Understanding of the underlying mechanism of drug resistance and identification of novel drug targets are key effective processes for the management of malaria. Malaria parasite is highly susceptible to oxidative stress but lives in a pro-oxidant rich environment containing oxygen and iron, which produce a large amount of reactive oxygen species. Management of oxidative stress in malaria parasite is tightly regulated through active redox and antioxidant defense systems. The elevation of oxidative stress as a result of inhibition of any component of this defense system leads to redox imbalance and ultimately parasite death. Therefore, redox system plays an indispensable role for the survival of parasite within the host. Identification of key molecules, which disrupt parasite redox balance by altering key redox reactions and promote oxidative stress in parasites, would be an effective approach to develop novel antimalarial drugs. During the last few decades, contributions by researchers around the globe provide even better understanding of redox biology of malaria parasite. Here, in this review, we are highlightin...Continue Reading

Citations

Apr 17, 2013·Journal of Medicinal Chemistry·Alexander P GorkaPaul D Roepe
Feb 13, 2014·Journal of Biomolecular Screening·Isabel ComaGonzalo Colmenarejo
Dec 17, 2014·Natural Product Reports·Martin J Schnermann, Ryan A Shenvi
May 4, 2016·Antimicrobial Agents and Chemotherapy·Souvik SarkarUday Bandyopadhyay
Aug 23, 2016·Molecular Informatics·Marco PersicoCaterina Fattorusso
Mar 13, 2019·Frontiers in Chemistry·Olaoluwa R ObisesanBhekie B Mamba

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