Redox regulation of autophagy in healthy brain and neurodegeneration

Neurobiology of Disease
Kenneth Hensley, Marni E Harris-White

Abstract

Autophagy and redox biochemistry are two major sub disciplines of cell biology which are both coming to be appreciated for their paramount importance in the etiology of neurodegenerative diseases including Alzheimer's disease (AD). Thus far, however, there has been relatively little exploration of the interface between autophagy and redox biology. Autophagy normally recycles macro-molecular aggregates produced through oxidative-stress mediated pathways, and also may reduce the mitochondrial production of reactive oxygen species through recycling of old and damaged mitochondria. Conversely, dysfunction in autophagy initiation, progression or clearance is evidenced to increase aggregation-prone proteins in neural and extraneural tissues. Redox mechanisms of autophagy regulation have been documented at the level of cross-talk between the Nrf2/Keap1 oxidant and electrophilic defense pathway and p62/sequestosome-1 (SQSTM1)-associated autophagy, at least in extraneural tissue; but other mechanisms of redox autophagy regulation doubtless remain to be discovered and the relevance of such processes to maintenance of neural homeostasis remains to be determined. This review summarizes current knowledge regarding the relationship of redox ...Continue Reading

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Citations

Jan 26, 2016·Journal of Neuroscience Methods·Nicolas K KhattarRobert M Friedlander
Jul 15, 2015·Neurobiology of Disease·D Allan Butterfield
Jul 30, 2015·Natural Product Research·Francesco MaioneNicola Mascolo
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Jul 1, 2019·European Journal of Medicinal Chemistry·Navneet KishoreAkhilesh Kumar Verma
Dec 27, 2016·Neuroscience Research·Akiko SumitomoToshifumi Tomoda

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