Redox regulation of ischemic limb neovascularization - What we have learned from animal studies

Redox Biology
Reiko MatsuiColin E Murdoch

Abstract

Mouse hindlimb ischemia has been widely used as a model to study peripheral artery disease. Genetic modulation of the enzymatic source of oxidants or components of the antioxidant system reveal that physiological levels of oxidants are essential to promote the process of arteriogenesis and angiogenesis after femoral artery occlusion, although mice with diabetes or atherosclerosis may have higher deleterious levels of oxidants. Therefore, fine control of oxidants is required to stimulate vascularization in the limb muscle. Oxidants transduce cellular signaling through oxidative modifications of redox sensitive cysteine thiols. Of particular importance, the reversible modification with abundant glutathione, called S-glutathionylation (or GSH adducts), is relatively stable and alters protein function including signaling, transcription, and cytoskeletal arrangement. Glutaredoxin-1 (Glrx) is an enzyme which catalyzes reversal of GSH adducts, and does not scavenge oxidants itself. Glrx may control redox signaling under fluctuation of oxidants levels. In ischemic muscle increased GSH adducts through Glrx deletion improves in vivo limb revascularization, indicating endogenous Glrx has anti-angiogenic roles. In accordance, Glrx overexpr...Continue Reading

Citations

Mar 8, 2018·In Vitro Cellular & Developmental Biology. Animal·Qun TangChunyan Liu
Apr 1, 2018·Arhiv za higijenu rada i toksikologiju·Kristina Dominko, Domagoj Đikić
Apr 19, 2018·Antioxidants & Redox Signaling·Katrin Schröder
Jun 2, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Sarah M PetersonLucy Liaw
Jan 18, 2018·Hypertension·Gabriele Giacomo SchiattarellaCinzia Perrino
Oct 28, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yoshimitsu YuraReiko Matsui
Sep 21, 2019·Scientific Reports·Toyokazu KimuraMarkus Michael Bachschmid
Dec 10, 2019·Antioxidants & Redox Signaling·Reiko MatsuiMarkus Michael Bachschmid
Sep 20, 2020·International Journal of Molecular Sciences·Mannix BurnsMarkus M Bachschmid
Nov 25, 2020·International Journal of Molecular Sciences·Tsuyoshi TakataYasuo Watanabe
Feb 23, 2021·Critical Reviews in Food Science and Nutrition·Xuan ChenZeyuan Deng
Mar 7, 2021·International Journal of Molecular Sciences·Rouven BerndtRené Rusch
Sep 12, 2020·Redox Biology·N A RashdanC B Pattillo
Jul 19, 2021·Basic Research in Cardiology·Ioanna AndreadouRainer Schulz

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Methods Mentioned

BETA
transgenic
ubiquitination
GTPase

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