Mar 27, 2020

Redox regulation of regulatory T-cell differentiation and functions

Free Radical Research
Raghavendra S PatwardhanSantosh K Sandur

Abstract

The choice between immunity or tolerance is a consequence of T-cell fate determined by T-cell receptor affinity to cognate MHC-peptide complex, costimulatory molecules and cytokines from antigen presenting cells. While activated, effector and memory T-cells provide immunity against antigens, regulatory T-cells play a pivotal non-redundant role in immune tolerance and tissue repair. T-cell differentiation and functions are also well known to be governed by the redox status. Physiological redox status is determined by oxygen concentration, reactive oxygen species levels and antioxidant concentration (vitamin C, glutathione, vitamin E). Cellular redox state influences the levels of oxygen-dependent ten-eleven translocase (TET) demethylase, hypoxia inducible factor-1α (HIF-1α), and metabolic reprogramming which in turn control the epigenetic modification, transcription, translation and post-translational stability of FoxP3, the master regulator of regulatory T-cell induction and maintenance. Redox changes during foetal development, pregnancy, ageing, infections and cancer bolster Treg differentiation for immune tolerance to non-dangerous non-self-antigens. Incidentally, the changes in blood oxygen levels in pregnant women and devel...Continue Reading

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Mentioned in this Paper

Vitamin E
Foxp3 protein, mouse
Protein Biosynthesis
Memory T-Lymphocyte
Antigen-Presenting Cells
Response to Redox State
Regulation of T Cell Differentiation
Reactive Oxygen Species
Prophylactic Treatment
Solid Tumour

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