Redox regulation of T-cell receptor signaling

Biological Chemistry
Luca Simeoni, Ivan Bogeski

Abstract

T-cell receptor (TCR) triggering by antigens activates a sophisticated intracellular signaling network leading to transcriptional activation, proliferation and differentiation of T cells. These events ultimately culminate in adaptive immune responses. Over recent years it has become evident that reactive oxygen species (ROS) play an important role in T-cell activation. It is now clear that ROS are involved in the regulation of T-cell mediated physiological and pathological processes. Upon TCR triggering, T cells produce oxidants, which originate from different cellular sources. In addition, within inflamed tissues, T cells are exposed to exocrine ROS produced by activated phagocytes or other ROS-producing cells. Oxidative modifications can have different effects on T-cell function. Indeed, they can stimulate T-cell activation but they can be also detrimental. These opposite effects of oxidation likely depend on different factors such as ROS concentration and source and also on the differentiation status of the T cells. Despite the well-stablished fact that ROS represent important modulators of T-cell activation, the precise molecular mechanisms of their action are far from clear. Here, we summarize the present knowledge on redo...Continue Reading

References

Apr 11, 1992·Lancet·F J StaalL A Herzenberg
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S B KannerJ A Ledbetter
May 14, 1992·Nature·T J MolinaA Veillette
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M SuthanthiranA Meister
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M A Goldsmith, A Weiss
Jan 1, 1986·Cellular Immunology·R K Fidelus, M F Tsan
Jan 1, 1985·Immunology Letters·M GerberA Crastes de Paulet
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A NovogrodskyK H Stenzel
Jan 1, 1995·European Journal of Immunology·M LosK Schulze-Osthoff
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·L A HerzenbergL A Herzenberg
Sep 1, 1996·The Journal of Experimental Medicine·G PaniK A Siminovitch
May 5, 1997·The Journal of Cell Biology·M HothR S Lewis
Jun 1, 1997·Current Opinion in Immunology·J C Unkeless, J Jin
Apr 30, 1998·Current Opinion in Cell Biology·T Finkel
Sep 18, 1998·Biochemistry and Molecular Biology International·J M CunnickJ Wu
Jan 16, 1999·Free Radical Biology & Medicine·S TatlaB M Chain
Mar 24, 1999·Archives of Biochemistry and Biophysics·J M TrevillyanS W Djurić
Jul 14, 1999·Immunity·D A HildemanP C Marrack
Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·M HothR S Lewis
Mar 23, 2001·Nature Immunology·J Roose, A Weiss
May 29, 2001·Current Medicinal Chemistry·P Kovacic, J D Jacintho
Dec 18, 2001·Mechanisms of Ageing and Development·Bulbul Chakravarti, George N Abraham
Dec 26, 2001·Science's STKE : Signal Transduction Knowledge Environment·R L Wange
Jan 5, 2002·Molecular and Cellular Biology·Sonja I GringhuisCornelis L Verweij
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Maddalena FratelliPietro Ghezzi
Sep 7, 2002·Antioxidants & Redox Signaling·Shugo UedaJunji Yodoi
Sep 7, 2002·Antioxidants & Redox Signaling·Anwarul A AkhandIzumi Nakashima
Oct 11, 2002·Free Radical Biology & Medicine·Kyoungmun Lee, Walter J Esselman
Nov 26, 2002·Nature Immunology·Michael Reth
Nov 28, 2002·Molecular Cell·Véronique RolliMichael Reth
Dec 18, 2002·The EMBO Journal·Maike D GlitschAnant B Parekh
Feb 20, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lizette GilOlga Sonia León
Mar 6, 2003·The Journal of Clinical Investigation·David A HildemanPhilippa Marrack

❮ Previous
Next ❯

Citations

Jan 23, 2016·Clinical Kidney Journal·Luca SimeoniAndreas Linkermann
Apr 22, 2016·Free Radical Research·Xiran Lin, Tian Huang
May 5, 2016·Cell Calcium·Christine S GibhardtIvan Bogeski
May 3, 2016·The Journal of Clinical Investigation·Moran BenharAndrea Savarino
Apr 10, 2015·Biological Chemistry·Johannes M HerrmannTobias P Dick
Oct 7, 2016·Nanoscale Research Letters·Toshiro HiraiYasuo Tsutsumi
Oct 25, 2016·Seminars in Immunology·Marcin M KamińskiDouglas R Green
Mar 14, 2017·Scientific Reports·Xiao ZhouBin Qu
Oct 11, 2017·Antioxidants & Redox Signaling·Dana M Previte, Jon D Piganelli
Dec 17, 2019·PloS One·José Antonio Sánchez-VillanuevaMaría Angélica Santana
Nov 10, 2017·Oxidative Medicine and Cellular Longevity·Inken LorenzenEva-Maria Hanschmann
Oct 27, 2020·Current Opinion in Physiology·Yinhu WangStefan Feske
Mar 16, 2021·Frontiers in Immunology·Gaurav AgrahariTae-Yoon Kim
Aug 29, 2021·Cell Death and Differentiation·Stella KarstenUlrika Warpman Berglund

❮ Previous
Next ❯

Methods Mentioned

BETA
PMA
electron paramagnetic resonance
biosensors
nuclear translocation

Software Mentioned

HyPer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved