Redox Responsive Hyaluronic Acid Nanogels for Treating RHAMM (CD168) Over-expressive Cancer, both Primary and Metastatic Tumors

Theranostics
Chenchen YangXiqun Jiang

Abstract

It remains a substantial challenge to targetedly deliver drug to both primary tumors and metastatic lesions employing a single nanoparticle delivery system. Here aiming at the receptor for hyaluronic acid mediated motility (RHAMM or CD168), a specific receptor for hyaluronic acid (HA), the bioreductive responsive HA nanogels loaded doxorubicin were prepared. The targeting effects of HA nanogels in high RHAMM-expressed cancer cells, primary and metastatic tumors were investigated. It was found that HA nanogels show a strongin vitroandin vivoRHAMM-mediated cellular uptake and drug delivery. The cellular uptake of HA nanogels in high RHAMM-expressed LNCaP and H22 cells was far more than the uptake in low RHAMM-expressed NIH3T3 cells. The IC50value of drug-loaded HA nanogels against H22 cells was lower than that of free drug.In vivoantitumor activity examinations showed that the HA nanogels not only had significantly superior antitumor efficacy in murine H22 and human LNCaP tumor-bearing mice but also exhibited much deep tumor penetration. The drug delivery of lymph node metastasis by systemically administering HA nanogels demonstrated that the HA nanogels could sufficiently increase drug concentration in metastatic lymph node by R...Continue Reading

Citations

Jul 3, 2019·Pharmaceutics·Kibeom KimJa-Hyoung Ryu
Nov 8, 2018·Pharmaceutics·Chiara Di MeoPietro Matricardi
Aug 8, 2019·Expert Opinion on Drug Delivery·Yu Sakurai, Hideyoshi Harashima
Jul 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Khalilalrahman DehvariJia-Yaw Chang
Dec 12, 2020·Biomaterials Science·Zhen LiJun Wu
Nov 30, 2019·Cellular Signalling·A Sainio, H Järveläinen
Nov 3, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shiqi HuYouqing Shen
Apr 4, 2021·Biomolecules·Aikaterini BerdiakiDragana Nikitovic
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Methods Mentioned

BETA
electrophoresis
fluorescence-activated cell sorting
FACS
imaging technique
light scattering
fluorescence imaging

Software Mentioned

Origin
FACS
ZEISS

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