Redox-responsive regulation of denitrification genes in Brucella

Molecular Microbiology
R Martin Roop, Clayton C Caswell

Abstract

Brucella strains encounter oxygen deprivation during their intracellular replication in host cells, and the capacity of these bacteria to utilize NO(3) as an alternative electron acceptor for respiration plays an important role in their successful adaption to their intracellular niche. In this issue of Molecular Microbiology, Carrica et al (2012). report that NtrY and NtrX comprise a redox-responsive two-component regulator in Brucella abortus 2308 that responds to decreasing levels of O(2) and induces the expression of this strain's denitrification genes. Thus, NtrYX joins the increasing number of genetic regulators that contribute to the metabolic versatility required for the virulence of Brucella strains in their mammalian hosts.

References

Oct 1, 1993·Trends in Genetics : TIG·L Guarente
Jun 5, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M L IshidaF O Pedrosa
Nov 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Stephan KohlerJean-Pierre Liautard
Jun 5, 2003·Trends in Microbiology·Stephan KöhlerJean Pierre Liautard
Feb 3, 2006·Journal of Bacteriology·Valérie HaineXavier De Bolle
Feb 24, 2006·Infection and Immunity·Séverine Loisel-MeyerVéronique Jubier-Maurin
Oct 16, 2009·Medical Microbiology and Immunology·R Martin RoopDaniel W Martin
Nov 22, 2011·Antioxidants & Redox Signaling·Emilio BuenoMaria J Delgado
Apr 13, 2012·Antioxidants & Redox Signaling·Aisha FarhanaAdrie J C Steyn
May 16, 2012·Molecular Microbiology·Mariela del Carmen CarricaFernando Alberto Goldbaum

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brucellosis (ASM)

Brucellosis is a bacterial infection caused by members of the genus brucella and remains one of the world's major zoonotic diseases. Discover the latest research on Brucellosis here.

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.

Brucellosis

Brucellosis is a bacterial infection caused by members of the genus brucella and remains one of the world's major zoonotic diseases. Discover the latest research on Brucellosis here.