Redox-sensitive mechanisms underlying vascular dysfunction in heart failure

Free Radical Research
J KonradiA Klinke

Abstract

Regardless of the progress in therapeutic drugs and devices to treat heart failure (HF) during the last few years, the clinical outcome of this disease remains deleterious. Impaired left ventricular function leads to neurohumoral activation, altered local shear forces, and hypoxia, which might give rise to inflammatory processes within the vasculature. Among those, the imbalance of the redox equilibrium toward increased concentrations of reactive oxygen species (ROS) is particularly important, as it affects the integrity of vascular function. Apart from injured or dysfunctional cardiomyocytes, vascular dysfunction has been demonstrated to play a crucial role in the development and progression of HF, which makes it an interesting target for new HF therapies. The mechanisms that initiate vascular dysfunction in HF pathogenesis and the processes leading to oxidative stress are not yet fully elucidated. However, oxidative stress promotes a variety of redox-sensitive mechanisms contributing to vascular dysfunction in HF. Here, we will summarize the sources of ROS in the vasculature, elucidate the impact of oxidative stress on functional and structural vascular remodeling, and consider the link to vascular dysfunction. Furthermore, w...Continue Reading

References

Oct 1, 1992·Hypertension·T ImaizumiA Takeshita
Apr 1, 1991·The Journal of Clinical Investigation·E RossitchJ P Cooke
Jun 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H P Rodemann, G A Müller
Dec 1, 1990·Journal of Molecular and Cellular Cardiology·A KrützfeldtH M Piper
Dec 1, 1990·Medicine and Science in Sports and Exercise·T J QuinnH W Olson
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A InoueT Masaki
Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·M M KanterN D Nequin
Apr 1, 1987·Circulation·W K Laskey, W G Kussmaul
Oct 1, 1993·Journal of the American College of Cardiology·K K HoD Levy
Jun 1, 1993·Journal of Hypertension·K HishikawaT Saruta
May 22, 1996·JAMA : the Journal of the American Medical Association·D LevyK K Ho
Jul 17, 1996·JAMA : the Journal of the American Medical Association·G S GinsburgN Rifai
Dec 1, 1995·Atherosclerosis·J L Sánchez-QuesadaJ Ordóñez-Llanos
Apr 1, 1997·International Journal of Sports Medicine·I MargaritisP Marconnet
Jul 1, 1997·The American Journal of Physiology·O CulicJ Schrader
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·P J PaganoM T Quinn
May 9, 1998·Journal of Molecular and Cellular Cardiology·J T BarronJ E Parrillo
May 15, 1998·Nature·G García-CardeñaW C Sessa
Jul 21, 1998·Journal of the American College of Cardiology·M A MathierM J Semigran
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·J Vásquez-VivarK A Pritchard
Sep 3, 1998·The Journal of Biological Chemistry·U Laufs, J K Liao
Dec 18, 1998·The Journal of Biological Chemistry·P MartásekB S Masters
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·E ClementiS Moncada
Jul 15, 1999·Biochemical and Biophysical Research Communications·T Hirano

❮ Previous
Next ❯

Citations

May 15, 2015·Free Radical Research·C L Hawkins, P Van Antwerpen
Nov 21, 2015·Life Sciences·Alessandra BielliAugusto Orlandi
Jul 20, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Esma YagdiMarc Diederich
Sep 22, 2016·Journal of the American Society of Hypertension : JASH·Wei YangRuizheng Shi
Jun 24, 2017·Oxidative Medicine and Cellular Longevity·Guillermo BodegaManuel R Ramírez
Jul 11, 2018·Clinical Science·Vanessa Obas, Ramachandran S Vasan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved