Redox Signaling by Reactive Electrophiles and Oxidants

Chemical Reviews
Saba ParvezYimon Aye

Abstract

The concept of cell signaling in the context of nonenzyme-assisted protein modifications by reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely complex topic that has been approached from numerous different and multidisciplinary angles. Our Review reflects on five aspects critical for understanding how nature harnesses these noncanonical post-translational modifications to coordinate distinct cellular activities: (1) specific players and their generation, (2) physicochemical properties, (3) mechanisms of action, (4) methods of interrogation, and (5) functional roles in health and disease. Emphasis is primarily placed on the latest progress in the field, but several aspects of classical work likely forgotten/lost are also recollected. For researchers with interests in getting into the field, our Review is anticipated to function as a primer. For the expert, we aim to stimulate thought and discussion about fundamentals of redox signaling mechanisms and nuances of specificity/selectivity and timing in this sophisticated yet fascinating arena at the crossroads of chemistry and biology.

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Citations

Dec 28, 2018·Chembiochem : a European Journal of Chemical Biology·Marcus J C LongYimon Aye
Jan 16, 2020·Biomolecules·Petr JežekLydie Plecitá-Hlavatá
Mar 7, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shunping ZangXiaoling Zhang
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Nov 2, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jesse R PoganikYimon Aye
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Apr 6, 2019·Frontiers in Chemistry·Marcus J C LongYimon Aye
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Jul 2, 2020·The Analyst·Shaoqing DongChao Lu
Nov 12, 2020·Chembiochem : a European Journal of Chemical Biology·Marcus J C Long
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Jan 12, 2021·Frontiers in Chemistry·Elisa CarrascoAlfonso Blázquez-Castro
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Feb 19, 2021·Biosensors & Bioelectronics·Shuang ZhaoGuixue Wang
Mar 27, 2019·Current Opinion in Chemical Biology·Marcus Jc LongYimon Aye
Apr 4, 2021·International Journal of Molecular Sciences·František BaluškaArthur S Reber
Oct 2, 2020·Chemical Research in Toxicology·Anatoly Zhitkovich
Oct 20, 2020·ACS Chemical Biology·Yan YuFrank C Schroeder
Apr 8, 2021·Chembiochem : a European Journal of Chemical Biology·Marcus J C LongYimon Aye
Apr 25, 2021·Redox Biology·Claudia Lennicke, Helena M Cochemé

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