Redox status of the testes and sperm of rats following exposure to 2,5-hexanedione

Redox Report : Communications in Free Radical Research
Isaac A AdedaraEbenezer O Farombi

Abstract

Exposure to 2,5-hexanedione (2,5-HD) is well known to be associated with reproductive dysfunctions in both humans and animals. However, the role of oxidative stress in 2,5-HD-induced toxicity in testes and sperm has not yet been studied. The present study investigated the influence of 2,5-HD on antioxidant systems in the testes and epididymal sperm of rats following exposure to 0, 0.25, 0.5, and 1% 2,5-HD in drinking water for 21 consecutive days. Administration of 0.5% 2,5-HD significantly (P < 0.05) decreased epididymis weight, whereas 1% 2,5-HD-treated rats showed significantly decreased body weight, testis, and epididymis weights compared with the control group. Exposure to 2,5-HD caused a significant dose-dependent increase in the activities of superoxide dismutase, catalase, and glutathione peroxidase in both testes and sperm compared with the control group. Moreover, 2,5-HD-exposed rats showed significant decrease in glutathione-S-transferase activity and glutathione level with concomitant significant elevation in the levels of hydrogen peroxide and malondialdehyde in both testes and sperm. Testicular and epididymal atrophy with significant, dose-dependent, decrease in epididymal sperm number, sperm motility, and viabili...Continue Reading

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Nov 8, 2014·Journal of Toxicology·Isaac A AdedaraEbenezer O Farombi

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Citations

Feb 14, 2021·Ecotoxicology and Environmental Safety·Jingjing Yang, Zhanjun Ma
Jun 4, 2018·Biochemical and Biophysical Research Communications·Isaac A AdedaraEbenezer O Farombi
Jul 6, 2021·BioMed Research International·Samir A E BashandyIbrahim M Alhazza

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