Redox Systems Biology: Harnessing the Sentinels of the Cysteine Redoxome.

Antioxidants & Redox Signaling
Jason M Held

Abstract

Significance: Cellular redox processes are highly interconnected, yet not in equilibrium, and governed by a wide range of biochemical parameters. Technological advances continue refining how specific redox processes are regulated, but broad understanding of the dynamic interconnectivity between cellular redox modules remains limited. Systems biology investigates multiple components in complex environments and can provide integrative insights into the multifaceted cellular redox state. This review describes the state of the art in redox systems biology as well as provides an updated perspective and practical guide for harnessing thousands of cysteine sensors in the redoxome for multiparameter characterization of cellular redox networks. Recent Advances: Redox systems biology has been applied to genome-scale models and large public datasets, challenged common conceptions, and provided new insights that complement reductionist approaches. Advances in public knowledge and user-friendly tools for proteome-wide annotation of cysteine sentinels can now leverage cysteine redox proteomics datasets to provide spatial, functional, and protein structural information. Critical Issues: Careful consideration of available analytical approaches...Continue Reading

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Citations

May 27, 2020·International Journal of Sports Medicine·Michalis G NikolaidisAntonios Matsakas
Jul 6, 2020·Antioxidants & Redox Signaling·Jennifer Selinski, Renate Scheibe
Jul 11, 2020·Pharmaceuticals·Raffaele FalsaperlaPiero Pavone
Aug 21, 2020·Cell Death & Disease·Caitlyn B BrashearsJason M Held
Sep 19, 2020·Journal of Experimental Botany·Francisco J CorpasJosé M Palma
Aug 24, 2020·Redox Biology·Nachiyappan VenkatachalamStanislav Engel
Mar 7, 2021·International Journal of Molecular Sciences·Pauline ChazelasJérôme Guillard
Sep 12, 2020·Redox Biology·Jenna L ClementsJason M Held
Aug 12, 2021·Redox Report : Communications in Free Radical Research·Ché S Pillay, Nolyn John
Aug 22, 2021·Free Radical Biology & Medicine·Anna NobleJames N Cobley
Sep 4, 2021·IUBMB Life·Nikos V MargaritelisMichalis G Nikolaidis

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Methods Mentioned

BETA
GTPases
biosensors
biosensor
acetylation
protein folding
Assay
nuclear magnetic resonance
sequence-based prediction
affinity purification
biopsies

Software Mentioned

PROPKA
BioPlex
_ PTM
MaxQuant
NetSurfP
Forcefield
MODELLER
Chimera

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