Redox-triggered activation of nanocarriers for mitochondria-targeting cancer chemotherapy

Nanoscale
Wei ZhouShi-Wen Huang

Abstract

The importance of mitochondrial delivery of an anticancer drug to cancer cells has been recognized to improve therapeutic efficacy. The introduction of lipophilic cations, such as triphenylphosphonium (TPP), onto the surface of nanocarriers was utilized to target mitochondria via strong electrostatic interactions between positively charged TPP and the negatively charged mitochondrial membrane. However, the highly positive charge nature of TPP leads to rapid clearance from the blood, decrease of circulation lifetime, and nonspecific targeting of mitochondria of cells. Here, we report a strategy for improving the anticancer efficacy of paclitaxel via redox triggered intracellular activation of mitochondria-targeting. The lipid-polymer hybrid nanoparticles (LPNPs) are composed of poly(d,l-lactide-co-glycolide) (PLGA), a TPP-containing amphiphilic polymer (C18-PEG2000-TPP) and a reduction-responsive amphiphilic polymer (DLPE-S-S-mPEG4000). The charges of TPP in LPNPs were almost completely shielded by surface coating of a PEG4000 layer, ensuring high tumor accumulation. After uptake by cancer cells, the surface charges of LPNPs were recovered due to the detachment of PEG4000 under intracellular reductive conditions, resulting in ra...Continue Reading

References

Nov 29, 2001·The Journal of Biological Chemistry·Jackie F KiddPeter Thorn
May 15, 2010·Nature Reviews. Drug Discovery·Simone FuldaGuido Kroemer
Feb 8, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ru ChengZhiyuan Zhong
Sep 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sean Marrache, Shanta Dhar
Nov 26, 2013·Advanced Drug Delivery Reviews·Nicolas BertrandOmid C Farokhzad
Dec 7, 2013·Biotechnology Advances·Juan LiuXing-Jie Liang
Mar 13, 2014·Nature Communications·Ran MoZhen Gu
Jul 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Sean MarracheShanta Dhar
Sep 25, 2014·Nanoscale·Quanyin HuZhen Gu
Oct 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Li TangJianjun Cheng
Dec 10, 2014·Nanomedicine·Amaraporn WongrakpanichAliasger K Salem
Sep 9, 2015·Nature Biotechnology·Elvin BlancoMauro Ferrari
Oct 21, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Phong LuCarol S Lim
Mar 2, 2016·Annals of Biomedical Engineering·Jicheng YuZhen Gu
Apr 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Hong-Jun LiJun Wang
May 8, 2016·Biomaterials·Xiaowei MaXing-Jie Liang
May 11, 2016·ACS Nano·Sukru Gokhan ElciRichard W Vachet
Aug 23, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Barbara GrünwaldMauro Comes Franchini
Nov 12, 2016·Nature Reviews. Cancer·Jinjun ShiOmid C Farokhzad
Jan 18, 2017·Journal of the American Chemical Society·Sabyasachi ChakraborttyTanja Weil
Feb 1, 2017·Angewandte Chemie·Chenggen QianZhen Gu
Apr 12, 2017·Advanced Materials·Pingqiang CaiXiaodong Chen

❮ Previous
Next ❯

Citations

Mar 15, 2019·Chemical Communications : Chem Comm·Dongqing WangYi Hu
Aug 6, 2019·Chemical Communications : Chem Comm·Yu GengYouqing Shen
Mar 5, 2020·Angewandte Chemie·Si Si LiewShao Q Yao
Sep 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Junho AhnJong Hwa Jung
Dec 29, 2020·Frontiers in Pharmacology·Jinfeng ShiChaomei Fu
Jun 25, 2021·International Journal of Nanomedicine·Yongjia HuangJingqing Zhang
May 29, 2019·ACS Applied Materials & Interfaces·Peng GaoBo Tang
Jun 20, 2020·ACS Applied Materials & Interfaces·Chaonan LiZhigang Xie
Aug 30, 2021·Advances in Colloid and Interface Science·Bijaideep DuttaP A Hassan

❮ Previous
Next ❯

Methods Mentioned

BETA
nanoprecipitation
dynamic light scattering
xenograft

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.