PMID: 8583833Sep 15, 1995Paper

Reduced ability of hypothalamic and pituitary extracts from old mice to stimulate thymulin secretion in vitro

Mechanisms of Ageing and Development
R G GoyaM Dardenne

Abstract

There is substantial evidence that growth hormone (GH) is particularly important in the control of the age-related decline of thymus function. It was therefore of interest: (a) to assess the overall capacity of tissue extracts from mediobasal hypothalamus (MBH), anterior pituitary (AP) and testis, obtained from young (3 months, Yc), middle-aged (13 months, MAc) and old (18 months, Oc) intact C57BL/6 mice to stimulate in vitro the release of thymulin, a Zn-bound immunoregulatory thymic peptide, from pure cultures of mouse thymic epithelial cells (TEC); (b) to perform the same evaluation utilizing MBH, AP and testicular extracts from mice of the same age-range but treated for 45 days with a sc dose of ovine GH (2 micrograms/g body wt) known to stimulate thymulin secretion in vivo. Pituitary hormones were measured by heterologous rat RIAs, whereas thymulin release was estimated by a rosette assay. Untreated animals showed a significant age-dependent increase in the AP content of follicle stimulating hormone but not in other AP hormones. In both control and treated animals, pituitary GH content decreased significantly with age. MBH extracts from C57BL/6 males evidenced thymulin-releasing activity on mouse TEC lines. This activity w...Continue Reading

References

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Sep 1, 1993·Neuroendocrinology·R G GoyaM Dardenne

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Citations

Mar 9, 2004·Peptides·Rodolfo G GoyaMireille Dardenne
Sep 29, 2011·Neuroimmunomodulation·Paula C ReggianiRodolfo G Goya
May 29, 2015·The Journal of Endocrinology·Shiping SuYunsheng Li
Feb 25, 2009·Annals of the New York Academy of Sciences·Paula C ReggianiRodolfo G Goya
Jan 9, 2010·Expert Opinion on Therapeutic Targets·Mário SantosAdelino Leite-Moreira

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