Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease

Digestion
Kenichiro TakahashiAkira Andoh

Abstract

The global alteration of the gut microbial community (dysbiosis) plays an important role in the pathogenesis of inflammatory bowel diseases (IBDs). However, bacterial species that characterize dysbiosis in IBD remain unclear. In this study, we assessed the alteration of the fecal microbiota profile in patients with Crohn's disease (CD) using 16S rRNA sequencing. Fecal samples from 10 inactive CD patients and 10 healthy individuals were subjected to 16S rRNA sequencing. The V3-V4 hypervariable regions of 16S rRNA were sequenced by the Illumina MiSeq™II system. The average of 62,201 reads per CD sample was significantly lower than the average of 73,716 reads per control sample. The genera Bacteroides, Eubacterium, Faecalibacterium and Ruminococcus significantly decreased in CD patients as compared to healthy controls. In contrast, the genera Actinomyces and Bifidobacterium significantly increased in CD patients. At the species level, butyrate-producing bacterial species, such as Blautia faecis, Roseburia inulinivorans, Ruminococcus torques, Clostridium lavalense, Bacteroides uniformis and Faecalibacterium prausnitzii were significantly reduced in CD patients as compared to healthy individuals (p < 0.05). These results of 16S rRNA...Continue Reading

Citations

Aug 2, 2016·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Richard GarceauMarc-Christian Domingo
Apr 14, 2017·Current Opinion in Gastroenterology·Heitor S P de Souza
Mar 14, 2017·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ali Mirza, Yang Mao-Draayer
Dec 21, 2017·Nutrients·Giorgio La FataRobert E Steinert
Dec 23, 2017·Inflammatory Bowel Diseases·Mirko Di RuscioGiovanni Latella
Mar 2, 2018·The Journal of Microbiology·Alex J La Reau, Garret Suen
Nov 8, 2018·Journal of Gastroenterology and Hepatology·Jindong ZhangLiping Duan
Jan 19, 2018·Clinical and Translational Gastroenterology·Ahmed MoustafaBrigid S Boland
Oct 7, 2016·Nature Medicine·Bjoern O Schroeder, Fredrik Bäckhed
Jul 3, 2019·Cells·Yvonne OligschlaegerRonit Shiri-Sverdlov
Dec 30, 2017·Clinical Journal of Gastroenterology·Atsushi NishidaAkira Andoh
Jan 18, 2018·PLoS Computational Biology·Rajita MenonKirill S Korolev
Dec 7, 2019·Journal of Cellular and Molecular Medicine·Qi SunYouxin Wang
Sep 5, 2019·Journal of Gastroenterology·Yoshiyuki Mishima, Ryan Balfour Sartor
Sep 22, 2019·Nutrients·Simona Di CaroFarooq Rahman
Jun 7, 2019·Gut·Janine van der GiessenGwenny Manel Fuhler
May 24, 2020·International Journal of Molecular Sciences·Yanfen Bai, Thomas J Mansell
Dec 25, 2019·Clinical and Translational Medicine·Dickson Kofi Wiredu OcanseyFei Mao
May 17, 2019·Terapevticheskiĭ arkhiv·N A DanilovaR A Abdulkhakov
May 29, 2020·Pharmacotherapy·Stephanie A FlowersJames C Lee
Jul 31, 2020·Gut Microbes·Ana Maldonado-ContrerasAndrew Hoffman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriotherapy

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Bacteriotherapy (ASM)

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Actinomycosis

Actinomycosis is a rare, chronic, and slowly progressive granulomatous disease caused by filamentous Gram positive anaerobic bacteria from the Actinomycetaceae family (genus Actinomyces). The disease is characterised by the formation of painful abscesses in the mouth, lungs,breast or gastrointestinal tract. Discover the latest research on actinomycosis here.