Reduced adaptation of a non-recombining neo-Y chromosome

Nature
Doris Bachtrog, B Charlesworth

Abstract

Sex chromosomes are generally believed to have descended from a pair of homologous autosomes. Suppression of recombination between the ancestral sex chromosomes led to the genetic degeneration of the Y chromosome. In response, the X chromosome may become dosage-compensated. Most proposed mechanisms for the degeneration of Y chromosomes involve the rapid fixation of deleterious mutations on the Y. Alternatively, Y-chromosome degeneration might be a response to a slower rate of adaptive evolution, caused by its lack of recombination. Here we report patterns of DNA polymorphism and divergence at four genes located on the neo-sex chromosomes of Drosophila miranda. We show that a higher rate of protein sequence evolution of the neo-X-linked copy of Cyclin B relative to the neo-Y copy is driven by positive selection, which is consistent with the adaptive hypothesis for the evolution of the Y chromosome. In contrast, the neo-Y-linked copies of even-skipped and roundabout show an elevated rate of protein evolution relative to their neo-X homologues, probably reflecting the reduced effectiveness of selection against deleterious mutations in a non-recombining genome. Our results provide evidence for the importance of sexual recombination...Continue Reading

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Citations

Dec 2, 2005·Journal of Molecular Evolution·Sofia Berlin, Hans Ellegren
Apr 26, 2007·Journal of Molecular Evolution·Doris Bachtrog
May 3, 2013·Molecular Genetics and Genomics : MGG·Robert VanBuren, Ray Ming
Nov 1, 2011·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Judith E Mank
Nov 16, 2011·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Darren K Griffin
Jun 13, 2003·Trends in Genetics : TIG·Gabriel Marais
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May 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hooman K MoghadamJudith E Mank
Aug 8, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jianping WangRay Ming
Oct 12, 2011·Genome Biology and Evolution·Vera B KaiserDoris Bachtrog
Sep 22, 2010·Molecular Biology and Evolution·Suo QiuDeborah Charlesworth
Jul 17, 2012·Molecular Biology and Evolution·Cheng-Ruei Lee, Thomas Mitchell-Olds
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Feb 8, 2007·Genome Biology·Penelope R HaddrillBrian Charlesworth
Feb 14, 2008·Genome Biology·Doris BachtrogPieter de Jong
May 1, 2009·PLoS Biology·Doris BachtrogZhi Zhang
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Nov 17, 2004·Genetics·Carolina BartoloméBrian Charlesworth
Mar 21, 2006·Genetics·Carolina Bartolomé, Brian Charlesworth
Oct 10, 2006·Genetics·Doris Bachtrog, Peter Andolfatto

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