Reduced adiposity by compensatory WAT browning upon iBAT removal in mice

Biochemical and Biophysical Research Communications
Zhengyu PiaoWanzhu Jin

Abstract

The strong effects of classic brown adipose tissue (BAT) and recruited beige adipocytes in treatment of obesity and metabolic syndrome have been attracting increasing research interest. Cold treatment is an effective, convenient approach to stimulate BAT activity and induce white adipose tissue (WAT) browning. Here, we utilized prolonged cold exposure (from 2 h to 2 weeks in a 4° cold chamber) to elucidate dynamic changes in BAT and in WAT browning during acute and chronic cold exposure in mice. BAT mass decreased quickly, with reduced lipid droplet sizes within 8 h of cold exposure owing to the utilization of BAT pre-storage triglycerides, and subsequently increased during prolonged cold exposure. These dynamic morphological changes in BAT were confirmed by gene expression changes in ADRB3 and PGC1α, while UCP1 and ELOVL3 expression was continuously up-regulated throughout the entire cold exposure period. Additionally, cold treatment increased BAT secretion of FGF21, which has been reported to activate beige adipocyte formation. Thus, to illustrate potential crosstalk between secreted BAT proteins (so-called BATokines) and beige adipogenesis during cold stress, we performed an interscapular BAT (iBAT) removal experiment in mic...Continue Reading

Citations

Jan 1, 2019·BioMed Research International·Tong XuDanfeng Yang
Aug 25, 2019·International Journal of Molecular Sciences·Xiaojuan LiangYanfang Wang
Jul 28, 2020·Frontiers in Endocrinology·Marlou Klein Hazebroek, Susanne Keipert
Dec 22, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Xiao-Wei JiaYan Gao

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