Abstract
Autoimmune, lupus-prone MRL-lpr mice float excessively in the forced swim test, explore novel objects and places less, and show blunted responsiveness to palatable stimuli, which is consistent with the hypothesis that the development of chronic autoimmune disease alters emotional reactivity and/or motivation. The present study measures isolation-induced fighting, a model of "affective" aggression, in lupus-prone MRL-lpr and control MRL +/+ males. When compared with controls, autoimmune MRL-lpr mice show reduced aggressiveness, as evidenced by fewer fighting contacts, longer attack latency, shorter fighting episodes and shorter duration of fighting. In addition, reduced testosterone levels accompany serological signs of autoimmunity in the MRL-lpr males. The present results support the hypothesis that affective responsiveness is altered in lupus-prone mice and may suggest limbic system dysfunction during chronic autoimmune/inflammatory disease. The question of whether immune activation alters behavior by a direct effect on the nervous system, or also via the endocrine system, requires further study.
References
Nov 1, 1992·Psychoneuroendocrinology·P F Brain, M Haug
Sep 1, 1992·Brain, Behavior, and Immunity·B SakićJ A Denburg
Oct 15, 1991·Experientia·R F BenusG A van Oortmerssen
Dec 1, 1991·Journal of Neuroimmunology·C M VogelweidS E Walker
Mar 1, 1991·International Immunology·B TangT Kishimoto
Jan 1, 1990·Pharmacology & Therapeutics·P Willner
Mar 26, 1986·Brain Research·J P DaVanzoM S Swanson
Dec 1, 1985·Clinical Rheumatology·M CarrabbaP Travaglini
Feb 1, 1972·Physiology & Behavior·B M Slotnick, M F McMullen
Aug 1, 1983·Annals of Neurology·E L AlexanderG E Alexander
Sep 1, 1994·Physiology & Behavior·B SakićJ A Denburg
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·R Bell, H Hobson
Jan 1, 1993·International Archives of Allergy and Immunology·Y HuG Wick
Nov 1, 1993·Physiology & Behavior·B SakićJ A Denburg
Sep 1, 1993·Behavior Genetics·S N Novikov
Oct 1, 1993·Lupus·J F SequeiraG R Hughes
Jun 1, 1993·Lupus·E Fonseca, G Rubio
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·J Haller
Sep 1, 1995·Neuroimmunomodulation·B L SpangeloW C Gorospe
Jan 1, 1996·Brain Research Bulletin·B SakićH Szechtman
Jan 1, 1997·Lupus·H SzechtmanJ A Denburg
Jan 1, 1997·Lupus·M FarrellJ A Denburg
May 1, 1997·Neuroscience and Biobehavioral Reviews·B SakićJ A Denburg
Jan 1, 1997·Brain Research Bulletin·B SakićJ A Denburg
Citations
Apr 16, 2004·Behavioural Brain Research·Amanda Kwant, Boris Sakic
Mar 20, 2003·Behavioural Brain Research·David A BallokBoris Sakic
Feb 19, 2011·Journal of Biomedicine & Biotechnology·Maria Gulinello, Chaim Putterman
Nov 7, 2000·Journal of Neuroimmunology·B SakicJ A Denburg
May 5, 1999·Journal of Neuroimmunology·B SakićS Rivest
Aug 6, 2002·Journal of Neuroimmunology·Boris SakicHenry Szechtman
Sep 4, 2014·Autoimmunity Reviews·Hélène Jeltsch-David, Sylviane Muller
Jul 17, 2012·Behavioural Brain Research·Minesh KapadiaBoris Sakic
Jan 16, 2007·Brain Research Reviews·David A Ballok
May 30, 2009·Arthritis and Rheumatism·John G SledBoris Sakic
Mar 23, 2005·Biological Psychiatry·Boris SakicJason M Millward
Jun 30, 2004·Journal of Neuroimmunology·David A BallokBoris Sakic
Sep 27, 2005·Behavioural Brain Research·Kelly K AndersonBoris Sakic
Mar 22, 2001·Brain, Behavior, and Immunity·B SakićH Szechtman
Feb 16, 2002·Brain, Behavior, and Immunity·Darci M Nielsen, Linda S Crnic
Aug 3, 2007·Lupus·G KökényP Hamar
Apr 13, 2017·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Minesh KapadiaBoris Sakic