Reduced alternative splicing of estrogen receptor alpha in the endometrium of women with endometriosis

Oncotarget
Ying ZhangHong Xu

Abstract

Endometriosis is a condition which involves the presence of uterine stroma and glands outside of the uterine cavity and represents one of the most prevalent disorders of the female reproductive tract. The key symptom of endometriosis is pain, including dysmenorrhea, deep dyspareunia, and chronic pelvic pain. As such, endometriosis has significant economic consequences within the healthcare system and can influence the daily quality of life in affected patients. However, the pathophysiology of this disease and the mechanisms in which this condition generates pain are very unclear. This study, involving 30 women with endometriosis and 28 controls without endometriosis, aimed to investigate relative levels of estrogen receptor alpha (ERα) splice variants in the endometrium of women with and without endometriosis and investigate potential links to the severity of pain. Wild type (wt)-ERα was dominantly expressed in human endometrium while the expression of ERα-del.4, ERα-del.7, and ERα-del.3,4 was significantly reduced in endometriosis patients compared with healthy patients (p < 0.05). Furthermore, the relative ratios of wtERα:ERα-del.4, and wtERα:ERα-del.3,4 were associated with the severity of pain in endometriosis patients (p <...Continue Reading

References

Dec 3, 1990·Molecular and Cellular Endocrinology·L C Murphy
Feb 10, 1989·Cell·M Beato
Nov 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·Q X ZhangA Borg
Dec 12, 2001·The Journal of Steroid Biochemistry and Molecular Biology·I Poola, V Speirs
Mar 26, 2003·The Journal of Steroid Biochemistry and Molecular Biology·J KitawakiH Honjo
Nov 4, 2005·Breast Cancer Research and Treatment·Sailaja KoduriBarbara K Vonderhaar
Oct 24, 2006·Fertility and Sterility·Xin GaoChris L Pashos
Jul 18, 2009·Cancer Letters·Siân E TaylorFrancis L Martin
Nov 9, 2010·Annual Review of Physiology·Albert Asante, Robert N Taylor
Jan 1, 2010·Journal of Laboratory Physicians·Neha Agarwal, Arulselvi Subramanian
Mar 30, 2013·Human Reproduction Update·Fernando M ReisRobert N Taylor
Dec 25, 2013·Nature Reviews. Endocrinology·Paolo VercelliniLuigi Fedele

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

SPSS

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Related Papers

Scandinavian Journal of Work, Environment & Health
Jennifer L MarinoScott Davis
The Cochrane Database of Systematic Reviews
Julie BrownMuhammad Akhtar
Journal of Ovarian Research
Doerthe BrueggmannKate Lawrenson
© 2022 Meta ULC. All rights reserved