Reduced amygdala reactivity and impaired working memory during dissociation in borderline personality disorder

European Archives of Psychiatry and Clinical Neuroscience
Annegret Krause-UtzBernet M Elzinga

Abstract

Affective hyper-reactivity and impaired cognitive control of emotional material are core features of borderline personality disorder (BPD). A high percentage of individuals with BPD experience stress-related dissociation, including emotional numbing and memory disruptions. So far little is known about how dissociation influences the neural processing of emotional material in the context of a working memory task in BPD. We aimed to investigate whole-brain activity and amygdala functional connectivity (FC) during an Emotional Working Memory Task (EWMT) after dissociation induction in un-medicated BPD patients compared to healthy controls (HC). Using script-driven imagery, dissociation was induced in 17 patients ('BPD_D'), while 12 patients ('BPD_N') and 18 HC were exposed to neutral scripts during fMRI. Afterwards, participants performed the EWMT with neutral vs. negative IAPS pictures vs. no distractors. Main outcome measures were behavioral performance (reaction times, errors) and whole-brain activity during the EWMT. Psychophysiological interaction analysis was used to examine amygdala connectivity during emotional distraction. BPD patients after dissociation induction showed overall WM impairments, a deactivation in bilateral...Continue Reading

References

Aug 5, 1966·Science·S Sternberg
Jun 1, 1995·NeuroImage·K J FristonR S Frackowiak
Nov 5, 1997·NeuroImage·K J FristonR J Dolan
Nov 10, 1998·Biological Psychiatry·M Sierra, G E Berrios
May 2, 2000·Psychological Review·M A Conway, C W Pleydell-Pearce
Nov 4, 2000·The American Journal of Psychiatry·D SimeonM S Buchsbaum
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Mar 5, 2003·Child Abuse & Neglect·David P BernsteinWilliam Zule
Aug 30, 2003·Biological Psychiatry·Mary L PhillipsRichard Lane
Sep 18, 2003·Stress : the International Journal on the Biology of Stress·Mary L Phillips, Mauricio Sierra
Sep 8, 2005·Developmental Neuropsychology·M Rosario RuedaMary K Rothbart
May 4, 2007·NeuroImage·Jason L SteinAndreas Meyer-Lindenberg
May 10, 2007·Developmental Neuropsychology·Erin D BiglerJanet E Lainhart
Jul 11, 2007·The Australian and New Zealand Journal of Psychiatry·Carsten SpitzerHans Joergen Grabe
Nov 22, 2007·Acta Psychiatrica Scandinavica·C E StiglmayrM Bohus
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Dec 27, 2008·NeuroImage·Amy Krain RoyMichael P Milham
Jan 6, 2009·Acta Psychiatrica Scandinavica·V Ø Haaland, N I Landrø
Jan 14, 2009·Neuroinformatics·Jan Gläscher
Feb 4, 2009·Current Psychiatry Reports·Marilyn I KorzekwaClare Pain
Apr 22, 2009·Psychological Bulletin·Sheila E CrowellMarsha M Linehan
Apr 29, 2009·Psychoneuroendocrinology·Nicole Y L OeiBernet M Elzinga
Dec 19, 2009·Journal of Behavior Therapy and Experimental Psychiatry·Chui-De ChiuChi-Chin Lin
Apr 3, 2010·The American Journal of Psychiatry·Ruth A LaniusDavid Spiegel
May 26, 2010·Cognitive, Affective & Behavioral Neuroscience·Alan AnticevicDeanna M Barch
Jan 5, 2011·Biological Psychiatry·Lars SchulzeSabine C Herpertz
Apr 19, 2011·Social Cognitive and Affective Neuroscience·Nicole Y L OeiBernet M Elzinga
Sep 13, 2011·Trends in Cognitive Sciences·Vinod Menon
Dec 3, 2011·Depression and Anxiety·David SpiegelPaul F Dell
Mar 13, 2012·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Susanne KamphausenOliver Tüscher
Jan 1, 2011·Brain Connectivity·Kathryn R CullenS Charles Schulz
May 10, 2012·Social Cognitive and Affective Neuroscience·Jill X O'ReillyHeidi Johansen-Berg
Oct 11, 2012·Journal of Psychiatry & Neuroscience : JPN·Gitta A JacobOliver Tüscher
Dec 20, 2012·Current Psychiatry Reports·Ryan W Carpenter, Timothy J Trull

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Citations

Mar 27, 2018·Current Behavioral Neuroscience Reports·Annegret Krause-Utz, Bernet Elzinga
Mar 16, 2019·Borderline Personality Disorder and Emotion Dysregulation·Martin BohusKathlen Priebe
Apr 2, 2020·European Journal of Pain : EJP·Boo Young ChungHerta Flor
Dec 4, 2020·Neuroscience and Biobehavioral Reviews·Monika I Roydeva, Antje A T S Reinders
Feb 20, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Christian ParetChristian Schmahl
Jun 9, 2019·Behaviour Research and Therapy·Ga In ShinSusannah Pick
May 8, 2021·Borderline Personality Disorder and Emotion Dysregulation·Julian D Ford, Christine A Courtois
May 26, 2021·Translational Psychiatry·Giorgia DegasperiClaudio Gentili
Sep 2, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Oskar ZarnowskiGabriela Santos-Nunez

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Software Mentioned

Automated Anatomical Labeling AAL
Statistical Parametric Mapping package ( SPM8
rfxplot
SPSS

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