Reduced antioxidant level and increased oxidative damage in intact liver lobes during ischaemia-reperfusion

World Journal of Gastroenterology : WJG
László VáliAnna Blázovics

Abstract

To determine whether increased blood flow of the liver can cause oxidative stress and hepatocyte damage, and to elaborate methods suitable for measuring the antioxidant defence during hepatic surgery on rat model. In nembutal narcosis, the left lateral and the medial lobes of the liver were clipped for 45 min to make the total blood supply flow through the other lobes. Total antioxidant status, glutathione peroxidase and superoxide dysmutase activity, as well as the concentrations of diene conjugates and free sulphydril groups, H-donating ability and reducing power of the liver samples were determined. Chemiluminescent intensity of the liver was also measured. Metal ions (Al, Ca, Cu, Fe, Mg, Mn, Zn) and P and S concentrations of the liver were determined with an inductively coupled plasma optical emission spectrometer and Se content was measured by cathodic stripping voltammetry. Glutathione peroxidase and superoxide dysmutase activities of the liver decreased significantly in the hyperemia group compared to those observed in the sham operated group. The level of total antioxidant status was also significantly lower in the hyperemia group. H-donating ability, reducing power and free sulphydril group concentration showed the sam...Continue Reading

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Citations

Feb 28, 2015·BioMed Research International·Soraya S BoschCarsten Wrenger
Nov 30, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Tom Luedde, Christian Trautwein
Jul 27, 2007·The British Journal of Nutrition·Alessandra BordoniPier Luigi Biagi
Mar 2, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Jie LinZhong Zeng
Jul 24, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Konstantinos KalimerisNikolaos Arkadopoulos

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