Reduced anxiety-like behavior in transgenic rats with chronically overproduction of angiotensin-(1-7): Role of the Mas receptor

Behavioural Brain Research
Lucas M KangussuMaria José Campagnole-Santos

Abstract

Angiotensin-(1-7) [Ang-(1-7)], a counterregulatory peptide of the renin-angiotensin system (RAS), exerts its cardiovascular and renal functions through the G-protein-coupled receptor Mas. More recently, Ang-(1-7) has also been implicated in the control of emotional states related to fear and anxiety. Here, we tested the hypothesis that transgenic rats overexpressesing Ang-(1-7) (TGR) show reduced anxiety-like behavior in two distinct animals models, the Elevated Plus Maze (EPM) and Vogel Conflict Test (VCT). Sprague-Dawley rats (SDs) were used as controls. In addition, we also verified whether this phenotype depend on activation of the Mas receptor. In line with our hypothesis, TGR rats showed an increase in the percentage of time and entries in the open arms of the EPM. There was also an increase in the number of punished licks in VCT. These phenotypes were reversed by ICV injection of the Mas receptor antagonist, A779, but not by the AT2 and MrgD receptor antagonist, PD123319. These results suggest that chronic elevation of Ang-(1-7) levels results in a phenotype characterized by reduced anxiety-like behavior, possibly due to higher activation of the Mas receptor. Therefore, facilitation of the Ang-(1-7)/Mas receptor signalin...Continue Reading

Citations

Mar 16, 2018·International Journal of Molecular Sciences·LaDonya JacksonAdviye Ergul
Dec 19, 2019·Protein and Peptide Letters·Lucas M KangussuAna Cristina Simões E Silva
Dec 24, 2019·Protein and Peptide Letters·Leonardo Augusto de Melo, Ana Flávia Almeida-Santos
Jan 15, 2020·Protein and Peptide Letters·Thatiane C G MachadoLucas M Kangussu
May 29, 2018·Clinical Science·Mariela M GironacciMauro G Silva
Aug 2, 2017·BMC Medicine·João VianBrisa S Fernandes
Nov 18, 2018·Neurochemical Research·Natalia Alenina, Michael Bader
Dec 12, 2020·Frontiers in Psychiatry·Fabio PanarielloAnna Rita Atti
Oct 5, 2021·Acta Neuropsychiatrica·Negar FirouzabadiVahid Ghanbarinejad
Oct 30, 2020·Pharmacology, Biochemistry, and Behavior·Sophocles ChrissobolisManoranjan S D'Souza

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