Reduced arterial vasodilatation in response to hypoxia impairs cerebral and peripheral oxygen delivery in hypertensive men

The Journal of Physiology
Igor A FernandesAntonio C L Nobrega

Abstract

Hypoxaemia evokes a repertoire of homeostatic adjustments that maintain oxygen supply to organs and tissues including the brain and skeletal muscles. Because hypertensive patients have impaired endothelial-dependent vasodilatation and an increased sympathetic response to arterial oxygen desaturation, we investigated whether hypertension impairs isocapnic hypoxia-induced cerebral and skeletal muscle hyperaemia to an extent that limits oxygen supply. In middle-aged hypertensive men, vertebral and femoral artery blood flow do not increase in response to isocapnic hypoxia, limiting brain and peripheral hyperaemia and oxygen supply. Increased chemoreflex-induced sympathetic activation impairs skeletal muscle perfusion and oxygen supply, whereas an attenuation of local vasodilatory signalling in the posterior cerebrovasculature reduced brain hyperperfusion of hypertensive middle-aged men in response to isocapnic hypoxia. The present study investigated whether hypertension impairs isocapnic hypoxia (IH)-induced cerebral and skeletal muscle hyperaemia to an extent that limits oxygen supply. Oxygen saturation (oxymetry), mean arterial pressure (photoplethysmography) and muscle sympathetic nerve activity (MSNA; microneugraphy), as well a...Continue Reading

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Citations

Jun 28, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lauro C ViannaAntonio C Nóbrega
Dec 7, 2018·The Journal of Physiology·João D MattosIgor A Fernandes
Dec 29, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Daniel E MansurIgor A Fernandes
Mar 22, 2019·Clinical Physiology and Functional Imaging·Niels D OlesenNiels H Secher
Mar 21, 2020·Journal of Hypertension·Vinicius P GarciaNatália G Rocha
May 23, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Milena SamoraJames P Fisher
May 29, 2020·The Journal of Physiology·Marcos P RochaIgor A Fernandes
Oct 24, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joao Dario MattosIgor A Fernandes
May 7, 2020·Journal of Hypertension·Vinicius P GarciaNatália G Rocha
Oct 29, 2020·Physiological Reports·Mattia BusanaAlessio Gasperetti
Nov 20, 2020·Journal of Applied Physiology·Shigehiko Ogoh, Damian M Bailey

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