Reduced Atherosclerosis in apoE-inhibitory FcγRIIb-Deficient Mice Is Associated With Increased Anti-Inflammatory Responses by T Cells and Macrophages

Arteriosclerosis, Thrombosis, and Vascular Biology
Hang Pong NgShanmugam Nagarajan

Abstract

Fcγ receptors (FcγRs) are classified as activating (FcγRI, III, and IV) and inhibitory (FcγRII) receptors. We have reported that deletion of activating FcγRs in apolipoprotein E (apoE) single knockout mice attenuated atherosclerosis. In this report, we investigated the hypothesis that deficiency of inhibitory FcγRIIb exacerbates atherosclerosis. ApoE-FcγRIIb double knockout mice, congenic to the C57BL/6 (apoE-FcγRIIbB6 (-/-)), were generated and atherosclerotic lesions were assessed. In contrary to our hypothesis, when compared with apoE single knockout mice, arterial lesions were significantly decreased in apoE-FcγRIIbB6 (-/-) male and female mice fed chow or high-fat diets. Chimeric mice generated by transplanting apoE-FcγRIIbB6 (-/-) marrow into apoE single knockout mice also developed reduced lesions. CD4(+) T cells from apoE-FcγRIIbB6 (-/-) mice produced higher levels of interleukin-10 and transforming growth factor-β than their apoE single knockout counterparts. As our findings conflict with a previous report using apoE-FcγRIIb129/B6 (-/-) mice on a mixed genetic background, we investigated whether strain differences contributed to the anti-inflammatory response. Macrophages from FcγRIIb129/B6 (-/-) mice on a mixed geneti...Continue Reading

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Citations

Jan 5, 2017·British Journal of Pharmacology·Andrew P Sage, Ziad Mallat
Feb 23, 2017·Biochemical and Biophysical Research Communications·Yi ShiShen-Ming Wang
Jan 29, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jillian P RhoadsAmy S Major
Jul 28, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Ziad Mallat
Sep 29, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Jacqueline S DronRobert A Hegele
May 17, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Jayashree Bagchi-ChakrabortyAndrew P Sage
Feb 9, 2017·Lipids in Health and Disease·Laura C Echeverri Tirado, Lina M Yassin
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May 14, 2021·Circulation Research·Xiaomin SongJing Wang
Jul 27, 2021·Frontiers in Immunology·Mark A HutchinsonRobert W Maul
Aug 28, 2021·Cardiovascular Research·Florentina PorschChristoph J Binder

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