Reduced auditory evoked gamma band response and cognitive processing deficits in first episode schizophrenia

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Gregor LeichtChristoph Mulert

Abstract

Gamma-band oscillations (e.g., the early auditory evoked gamma-band response, aeGBR) have been suggested to mediate cognitive and perceptual processes by driving the synchronization of local neuronal populations. Reduced aeGBR is a consistent finding in patients with schizophrenia and high-risk subjects, and has been proposed to represent an endophenotype for the illness. However, it is still unclear whether this reduction represents a deficit in sensory or cognitive processes, or a combination of the two. The present study investigated this question by manipulating the difficulty of an auditory reaction task in patients with first-episode schizophrenia and healthy controls. A 64-channel EEG was recorded in 23 patients with first-episode schizophrenia and 22 healthy controls during two conditions of an auditory reaction task: an easy condition that merely required low-level vigilance, and a difficult condition that placed significant demands on attention and working memory. In contrast to healthy controls, patients failed to increase aeGBR power and phase-locking in the difficult condition. In patients, aeGBR power and phase-locking indices were associated with working memory deficits. The observed results confirm the applicabi...Continue Reading

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Oct 21, 2015·Sleep Science·Edgar Garcia-RillFrancisco J Urbano
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May 22, 2021·Frontiers in Psychiatry·Andrea PerrottelliArmida Mucci
Jul 10, 2021·Translational Neuroscience·Caroline Lahogue, Didier Pinault

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