Reduced azithromycin susceptibility in Shigella sonnei, United States

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Rebecca Leigh HowieJean M Whichard

Abstract

To investigate azithromycin susceptibility in Shigella sonnei in the United States, we examined the azithromycin minimum inhibitory concentrations (MICs) of outbreak and routine human S. sonnei isolates. Isolate susceptibility clustered at 8 mg/L, but three isolates displayed higher MICs (>64  mg/L) to azithromycin. All three isolates contained a plasmid-encoded mphA gene, known to encode a macrolide-2'-phosphotransferase enzyme. Transformation of the mphA gene into Escherichia coli DH10B allowed the transfer of decreased susceptibility to azithromycin. Although these isolates might traditionally be defined as resistant, there are no established breakpoints for resistance to confirm that treatment of these isolates with azithromycin would fail, which complicates susceptibility screening.

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Citations

Jul 23, 2013·International Journal of Antimicrobial Agents·Cláudia GomesJoaquim Ruiz
Nov 28, 2012·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Cláudia GomesJoaquim Ruiz
Jun 22, 2011·Antimicrobial Agents and Chemotherapy·Maria Sjölund-KarlssonJean M Whichard
Jan 1, 2013·Antimicrobial Agents and Chemotherapy·Maria Sjölund KarlssonJean M Whichard
Apr 23, 2014·Emerging Infectious Diseases·Christiane GaudreauSadjia Bekal
Jan 24, 2012·The Journal of Infection·Margaret L PfeifferTheresa J Ochoa
Jul 5, 2015·The Journal of Antimicrobial Chemotherapy·Gregory H TysonShaohua Zhao
Apr 14, 2016·The American Journal of Gastroenterology·Mark S RiddleBradley A Connor
Jul 16, 2015·Transactions of the Royal Society of Tropical Medicine and Hygiene·Anicia M MedinaJoaquim Ruiz
May 23, 2015·International Journal of Medical Microbiology : IJMM·Angela LluqueJoaquim Ruiz
May 26, 2015·Clinics in Laboratory Medicine·Romney M Humphries, Audrey N Schuetz
Aug 18, 2016·Emerging Infectious Diseases·Kamonporn PoramathikulBrett Swierczewski
Oct 22, 2016·Frontiers in Microbiology·Li WangDongsheng Zhou
Nov 15, 2016·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Chuanling ZhangQingzhong Liu
May 24, 2018·Paediatrics and International Child Health·Phoebe C M Williams, James A Berkley
Jul 7, 2016·Antimicrobial Agents and Chemotherapy·Patrick F McDermottShaohua Zhao
Nov 18, 2014·Expert Review of Anti-infective Therapy·Karl C Klontz, Nalini Singh
Aug 17, 2016·Cold Spring Harbor Perspectives in Medicine·Corey FyfeJoyce Sutcliffe
Nov 15, 2011·Current Opinion in Gastroenterology·Herbert L DuPont
Oct 28, 2016·Critical Reviews in Microbiology·Cláudia GomesJoaquim Ruiz

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Datasets Mentioned

BETA
GQ274931.1
EU935739.1
AB366440.1

Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

Lasergene

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