Reduced baroreflex control of heart period after bed rest is normalized by acute plasma volume restoration

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Ken-Ichi IwasakiBenjamin D Levine

Abstract

Adaptation to spaceflight or head-down-tilt bed rest leads to hypovolemia and an apparent abnormality of baroreflex regulation of cardiac period. In a previous study, we demonstrated that both chronic (2 wk) head-down-tilt bed rest and acute induced hypovolemia led to similar impairments in spontaneous baroreflex control of cardiac period, suggesting that a reduction in plasma volume may be responsible for this abnormality after bed rest. Therefore we hypothesized that this reduced "baroreflex function" could be restored by intravenous volume infusion equivalent to the reduction in plasma volume after bed rest. Six healthy subjects underwent 2 wk of -6 degrees head-down bed rest. Beat-by-beat arterial blood pressure and ECG were recorded during 6 min of spontaneous respiration and fixed-rate breathing (0.2 Hz), and transfer function analysis between systolic blood pressure and R-R interval was performed. Plasma volume was measured with Evans blue dye, and cardiac filling pressures were directly measured (Swan-Ganz catheter). After bed rest, studies were repeated before and after plasma volume restoration, with which both plasma volume and left ventricular end-diastolic pressure were restored to pre-bed rest levels by intravenou...Continue Reading

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Citations

Jul 31, 2007·European Journal of Applied Physiology·A Pavy-Le TraonJ Vernikos
Nov 15, 2008·European Journal of Applied Physiology·M BuchheitS Ahmaidi
Aug 27, 2014·Autonomic Neuroscience : Basic & Clinical·Ryo YanagidaKen-ichi Iwasaki
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