Reduced basal forebrain and hippocampal activation during memory encoding in girls with fragile X syndrome

Neuroreport
Michael D GreiciusAllan Reiss

Abstract

Fragile X syndrome (FraX), the most common heritable cause of developmental disability, is associated with IQ, memory, and visuospatial processing deficits. The fragile X gene (FMR1) is prominently transcribed in two regions critical to memory encoding and attention: the hippocampus and the basal forebrain. To probe functional MRI activation abnormalities associated with the disorder, girls with FraX and age-matched, normally-developing girls were scanned during a test of visual memory encoding. While there were considerable similarities in activation patterns between the two groups, the girls with FraX showed significantly less activation in the hippocampus and the basal forebrain. This is the first study, to our knowledge, demonstrating functional deficits in FraX subjects in brain regions known to have the highest FMR1 transcription.

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Citations

Nov 1, 2011·Expert Opinion on Medical Diagnostics·Naama Barnea-Goraly, Antonio Hardan
Nov 5, 2008·Journal of the American Academy of Child and Adolescent Psychiatry·Cindy C HaganAllan L Reiss
Oct 6, 2009·Cognitive Systems Research·Mina C Johnson-Glenberg
Jan 11, 2007·Research in Developmental Disabilities·Chwen-Yng SuChing-Chiang Chen
Dec 17, 2009·Developmental Disabilities Research Reviews·A SchneiderD Hessl
Dec 17, 2009·Developmental Disabilities Research Reviews·Amy A Lightbody, Allan L Reiss
Oct 22, 2005·Mental Retardation and Developmental Disabilities Research Reviews·Doron GothelfAllan L Reiss
Apr 11, 2009·Autism Research : Official Journal of the International Society for Autism Research·Kim M DaltonRichard J Davidson
Feb 14, 2009·American Journal of Medical Genetics. Part a·Shelli R KeslerAllan L Reiss
Nov 22, 2013·American Journal of Medical Genetics. Part a·G E UtineM Alikaşifoğlu
Jun 15, 2007·Child and Adolescent Psychiatric Clinics of North America·Allan L Reiss, Scott S Hall
Jan 9, 2009·American Journal of Mental Retardation : AJMR·Peter A OrnsteinDonald B Bailey
Jun 28, 2016·Neuroscience and Biobehavioral Reviews·Crystal BostromBrian R Christie
Dec 22, 2019·Genes·Andrew G McKechanieAndrew C Stanfield

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