Reduced Blood Coagulation on Roll-to-Roll, Shrink-Induced Superhydrophobic Plastics

Advanced Healthcare Materials
Jolie M NokesMichelle Khine

Abstract

The unique antiwetting properties of superhydrophobic (SH) surfaces prevent the adhesion of water and bodily fluids, including blood, urine, and saliva. While typical manufacturable approaches to create SH surfaces rely on chemical and structural modifications, such approaches are expensive, require postprocessing, and are often not biocompatible. By contrast, it is demonstrated that purely structural SH features are easily formed using high throughput roll-to-roll (R2R) manufacturing by shrinking a prestressed thermoplastic with a thin, stiff layer of silver and calcium. These features are subsequently embossed into any commercially available and Food and Drug Administration (FDA)-approved plastic. The R2R SH surfaces have contact angles >150° and contact angle hysteresis <10°. Importantly, the surfaces minimize blood adhesion, leading to reduced blood coagulation without the need for anticoagulants. SH surfaces have >4200× reduction of blood residue area compared to the nonstructured controls of the same material. In addition, blood clotting is reduced >5× using whole blood directly from the patient. Furthermore, these surfaces can be easily configured into 3D shapes, as demonstrated with SH tubes. With the simple scale-up pr...Continue Reading

References

Sep 1, 1977·British Medical Bulletin·J F Mustard, M A Packham
Nov 1, 1991·The American Journal of Emergency Medicine·R Renzi, S Finkbeiner
May 20, 1988·Cell·B Furie, B C Furie
Jun 24, 2003·Nature Materials·Aurélie Lafuma, David Quéré
Jan 8, 2004·Journal of the American Chemical Society·Xinjian FengDaoben Zhu
Nov 3, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·G McHaleM I Newton
Jan 26, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Reiner FürstnerPeter Walzel
Jun 1, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Minglin MaGregory C Rutledge
Sep 21, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Baitai Qian, Ziqiu Shen
Nov 16, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·G McHaleH Y Erbil
May 17, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Tommaso BaldacchiniEric Mazur
Jun 28, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Lichao Gao, Thomas J McCarthy
Mar 6, 2007·Journal of Materials Science. Materials in Medicine·V PesskováL Himmlová
Jun 9, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Nigel MackmanNigel S Key
Nov 6, 2008·Journal of Biomedical Materials Research. Part a·Natália M AlvesJoão F Mano
Apr 28, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Albert PowerDavid Taube
Jul 7, 2009·Colloids and Surfaces. B, Biointerfaces·V N KazakovR Miller
Jul 16, 2010·Colloids and Surfaces. B, Biointerfaces·Xiaomei HouJian Shen
Aug 24, 2012·PloS One·Lauren R FreschaufMichelle Khine
Feb 1, 2014·Chemical Society Reviews·Zonglin Chu, Stefan Seeger
Oct 13, 2014·Nature Biotechnology·Daniel C LeslieDonald E Ingber

❮ Previous
Next ❯

Citations

Mar 5, 2016·Applied Physics Letters·Joshua KimMichelle Khine
Feb 22, 2018·Advanced Materials·Ville JokinenRobin H A Ras
Nov 24, 2017·Scientific Reports·Sasha HoshianVille Jokinen
Nov 23, 2019·Nanoscale·Zhihao Li, Zhiguang Guo
Jan 30, 2020·Biomaterials Science·Haifeng Fan, Zhiguang Guo
May 29, 2021·Colloids and Surfaces. B, Biointerfaces·Nusret CelikM Serdar Onses
Aug 10, 2021·Advanced Science·Lingyu SunYuanjin Zhao
Dec 30, 2017·ACS Applied Materials & Interfaces·Alexander DavisAthanassia Athanassiou
Apr 23, 2020·ACS Applied Materials & Interfaces·Anthony J GalantePaul W Leu
Mar 28, 2017··Sophia LinGaston A. O. Pezzani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

The Journal of Laboratory and Clinical Medicine
T H SPAETM KROPATKIN
Deutsche medizinische Wochenschrift
D Helberg
Cincinnati Journal of Medicine
R A JUBELIRER
© 2022 Meta ULC. All rights reserved